Nanoparticles as drug delivery systems: a review of the implication of nanoparticles' physicochemical properties on responses in biological systems
In the last four decades, nanotechnology has gained momentum with no sign of slowing
down. The application of inventions or products from nanotechnology has revolutionised all …
down. The application of inventions or products from nanotechnology has revolutionised all …
Polymeric micelles in cancer therapy: State of the art
In recent years, polymeric micelles have been extensively utilized in pre-clinical studies for
delivering poorly soluble chemotherapeutic agents in cancer. Polymeric micelles are formed …
delivering poorly soluble chemotherapeutic agents in cancer. Polymeric micelles are formed …
Nanopharmaceuticals and nanomedicines currently on the market: challenges and opportunities
There has been a revolution in nanotechnology and nanomedicine. Since 1980, there has
been a remarkable increase in approved nano-based pharmaceutical products. These novel …
been a remarkable increase in approved nano-based pharmaceutical products. These novel …
Lipid-based drug delivery systems in cancer therapy: what is available and what is yet to come
P Yingchoncharoen, DS Kalinowski… - Pharmacological …, 2016 - ASPET
Cancer is a leading cause of death in many countries around the world. However, the
efficacy of current standard treatments for a variety of cancers is suboptimal. First, most …
efficacy of current standard treatments for a variety of cancers is suboptimal. First, most …
Recent advances in polymeric micelles for anti-cancer drug delivery
Block co-polymeric micelles receive increased attention due to their ability to load
therapeutics, deliver the cargo to the site of action, improve the pharmacokinetic of the …
therapeutics, deliver the cargo to the site of action, improve the pharmacokinetic of the …
Design of functional nanoparticles by microfluidic platforms as advanced drug delivery systems for cancer therapy
Nanoparticle systems are functional carriers that can be used in the cancer therapy field for
the delivery of a variety of hydrophobic and/or hydrophilic drugs. Recently, the advent of …
the delivery of a variety of hydrophobic and/or hydrophilic drugs. Recently, the advent of …
Perfluorooctanoic acid (PFOA) exposures and incident cancers among adults living near a chemical plant
V Barry, A Winquist, K Steenland - Environmental health …, 2013 - ehp.niehs.nih.gov
Background: Perfluorooctanoic acid (PFOA) is a synthetic chemical ubiquitous in the serum
of US residents. It causes liver, testicular, and pancreatic tumors in rats. Human studies are …
of US residents. It causes liver, testicular, and pancreatic tumors in rats. Human studies are …
[图书][B] Drug-like properties: concepts, structure design and methods from ADME to toxicity optimization
L Di, EH Kerns - 2015 - books.google.com
Of the thousands of novel compounds that a drug discovery project team invents and that
bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution …
bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution …
Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles
H Wang, Y Zhao, Y Wu, Y Hu, K Nan, G Nie, H Chen - Biomaterials, 2011 - Elsevier
The use of single chemotherapeutic drug has shown some limitations in anti-tumor
treatment, such as development of drug resistance, high toxicity and limited regime of …
treatment, such as development of drug resistance, high toxicity and limited regime of …
Micellar nanocarriers: pharmaceutical perspectives
VP Torchilin - Pharmaceutical research, 2007 - Springer
Micelles, self-assembling nanosized colloidal particles with a hydrophobic core and
hydrophilic shell are currently successfully used as pharmaceutical carriers for water …
hydrophilic shell are currently successfully used as pharmaceutical carriers for water …