Abstract Expression of cyclooxygenase-2 (COX-2) has been linked to many cancers and
may contribute to malignant phenotypes, including enhanced proliferation, angiogenesis …

Cancer is a severe health condition and considered one of the major healthcare issues and
is in need of innovative strategy for a cure. The current study aimed to investigate the …

The last few years have seen a significant increase in our understanding of the molecular
pathways governing cell function in cancer. This has led to an explosive interest in novel …

Therapeutics that target the epidermal growth factor receptor (EGFR) can enhance the
cytotoxic effects of ionizing radiation (IR). However, predictive genomic biomarkers of this …

Per1 and Per2 play a key role in regulating the circadian rhythm in mammals. We report
here that although both genes were expressed with a circadian rhythm in glioma and normal …

PURPOSE: The purpose of the study was to elucidate the molecular mechanisms mediating
radiosensitization of human tumor cells by the selective cyclooxygenase (COX)-2 inhibitor …

Purpose Accumulating evidence suggests that microRNAs (miRNAs) possess diverse
cellular regulatory roles in radiation responses. In this study, we aimed to identify the role of …

Purpose Inhibitors of epidermal growth factor receptor (EGFR) have shown dramatic results
in a subset of patients with non-small cell lung cancer (NSCLC), and have also been shown …

Abbreviations: HDS, high density survival; CFA, colonyforming ability; CaMKII,
calcium/calmodulin-dependent protein kinase II; PI3K, phosphatidylinositol 3-kinase; PBS …

Abstract Cyclooxygenase-2 (COX-2) inhibitors are being developed as chemopreventive
and anticancer agents. This study aimed to determine the biological effect of the COX-2 …