Importance Parkinson disease is the most common form of parkinsonism, a group of
neurological disorders with Parkinson disease–like movement problems such as rigidity …

Tremor is one of the primary motor symptoms of Parkinson's disease (PD), and it is
characterized by a highly phenomenological heterogeneity. Clinical and experimental …

Tremor is one of the core symptoms of Parkinson's disease (PD), but its mechanism is poorly
understood. The cerebellum is a growing focus in PD-related researches and is reported to …

Objective We tested the hypothesis that there are 2 distinct phenotypes of Parkinson tremor,
based on interindividual differences in the response of resting tremor to dopaminergic …

Background: Tremor is one of the most prevalent symptoms in Parkinson's Disease (PD).
The progression and management of tremor in PD can be challenging, as response to …

Parkinson's tremor is related to cerebral activity in both the basal ganglia and a cerebello-
thalamo-cortical circuit. It is a common clinical observation that tremor markedly increases …

Rest tremor in Parkinson's disease is related to cerebral activity in both the basal ganglia
and a cerebello-thalamo-cortical circuit. Clinically, there is strong interindividual variation in …

The prodromal phase of Parkinson's disease is characterized by aggregation of the
misfolded pathogenic protein α-synuclein in select neural centres, co-occurring with non …

Imaging markers sensitive to neurodegeneration in the substantia nigra are critically needed
for future disease-modifying trials. Previous studies have demonstrated the utility of posterior …

The pathophysiology of Parkinson's disease (PD) tremor remains incompletely understood
and there is a lack of clinical trials specifically addressing its pharmacological treatment …