Sepsis-associated encephalopathy: From pathophysiology to clinical management

Y Hong, P Chen, J Gao, Y Lin, L Chen… - International …, 2023 - Elsevier
Sepsis-associated encephalopathy, which presents as delirium and coma, is a significant
complication of sepsis characterized by acute brain dysfunction. The presence of …

Acute and long-term cognitive impairment following sepsis: mechanism and prevention

MH Ji, YZ Gao, CN Shi, XM Wu… - Expert Review of …, 2023 - Taylor & Francis
Introduction Sepsis is a severe host response to infection, which induces both acute and
long-term cognitive impairment. Despite its high incidence following sepsis, the underlying …

Impairments of GABAergic transmission in hippocampus mediate increased susceptibility of epilepsy in the early stage of Alzheimer's disease

R Mao, M Hu, X Liu, L Ye, B Xu, M Sun, S Xu… - Cell Communication and …, 2024 - Springer
Abstract Background Patients with Alzheimer's disease (AD) are often co-morbid with
unprovoked seizures, making clinical diagnosis and management difficult. Although it has …

Genes Involved by Dexamethasone in Prevention of Long-Term Memory Impairment Caused by Lipopolysaccharide-Induced Neuroinflammation

GT Shishkina, TS Kalinina, DA Lanshakov… - Biomedicines, 2023 - mdpi.com
Inflammatory activation within the brain is linked to a decrease in cognitive abilities;
however, the molecular mechanisms implicated in the development of inflammatory-related …

Involvement of cannabinoid receptors and neuroinflammation in early sepsis: Implications for posttraumatic stress disorder

ME Matias, DR Radulski, TR da Silva… - International …, 2023 - Elsevier
Sepsis is associated with several comorbidities in survivors, such as posttraumatic stress
disorder (PTSD). This study investigated whether rats that survive sepsis develop the …

ErbB4 deficiency exacerbates olfactory dysfunction in an early-stage Alzheimer's disease mouse model

X Deng, X Liu, Y Wei, K Wang, J Zhu, J Zhong… - Acta Pharmacologica …, 2024 - nature.com
Olfactory dysfunction is increasingly recognized as an early indicator of Alzheimer's disease
(AD). Aberrations in GABAergic function and the excitatory/inhibitory (E/I) balance within the …

[HTML][HTML] Severe inflammation in C57/BL6 mice leads to prolonged cognitive impairment by initiating the IL-1β/TRPM2 pathway

Y Yang, Z Yao, H Wang, S Jia, M Wang, S Wang… - International …, 2024 - Elsevier
Background Sepsis could lead to chronic cognitive impairment by unclear molecular
mechanisms. Transient receptor potential melastatin-2 (TRPM2) is essential against …

Decreased serum VEGF and NRG1β1 levels in male patients with chronic schizophrenia: VEGF correlation with clinical symptoms and cognitive deficits

P Chen, W Chen, L Xu, L Luan, R Peng… - Journal of Psychiatric …, 2024 - Elsevier
Background Vascular endothelial growth factor (VEGF) and neuregulin1 (NRG1) are
multifunctional trophic factors reported to be dysregulated in schizophrenia. However, the …

[PDF][PDF] Screening and identification of key biomarkers associated with endometriosis using bioinformatics and next-generation sequencing data analysis

B Vastrad, C Vastrad - Egyptian Journal of Medical Human Genetics, 2024 - Springer
Background Endometriosis is a common cause of endometrial-type mucosa outside the
uterine cavity with symptoms such as painful periods, chronic pelvic pain, pain with …

Tetramethylpyrazine improves rats with sepsis-associated encephalopathy through regulation of autophagy signaling pathway

H Zhu, Y Zhang, H Zhou, J Wu, Y Chen, Z Lu, C Huang - 2024 - researchsquare.com
Background Tetramethylpyrazine, an alkaloid extracted from Ligusticum chuanxiong Hort
(Umbelliferae), has been used in China for cardiovascular and cerebrovascular diseases …