The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and
studied in the regulation of glycogen synthesis. GSK-3 functions in a wide range of cellular …

Abstract The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by
genetic alterations in upstream signaling molecules such as receptor tyrosine kinases …

BACKGROUND. Poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer
(ATC) are rare and frequently lethal tumors that so far have not been subjected to …

Purpose: Thyroid cancer cell lines are valuable models but have been neglected in
pancancer genomic studies. Moreover, their misidentification has been a significant …

Tumours can arise from thyroid follicular cells if they acquire driver mutations that
constitutively activate the MAPK signalling pathway. In addition, a limited set of additional …

Anaplastic thyroid carcinoma (ATC) has among the worst prognoses of any solid
malignancy. The low incidence of the disease has in part precluded systematic clinical trials …

The human six‐transmembrane epithelial antigen of the prostate (STEAP) protein family
contains at least five homologous members. The necessity of multiple homologous STEAP …

Differentiated thyroid cancers (DTCs) are primarily initiated by mutations that activate the
MAPK signaling cascade, typically at BRAF or RAS oncoproteins. DTCs can evolve to more …

Background: Anaplastic thyroid carcinoma (ATC) is a rare tumor, with poorly defined
oncogenic molecular mechanisms and limited therapeutic options contributing to its poor …

Thyroid malignancies are the most common type of endocrine tumors. Of the various
histologic subtypes, anaplastic thyroid carcinoma (ATC) represents a subset of all cases but …