Autoimmune CD8+ T cells in type 1 diabetes: from single-cell RNA sequencing to T-cell receptor redirection
K Yang, Y Zhang, J Ding, Z Li, H Zhang… - Frontiers in …, 2024 - frontiersin.org
Type 1 diabetes (T1D) is an organ-specific autoimmune disease caused by pancreatic β cell
destruction and mediated primarily by autoreactive CD8+ T cells. It has been shown that …
destruction and mediated primarily by autoreactive CD8+ T cells. It has been shown that …
[HTML][HTML] Oncogenic STAT transcription factors as targets for cancer therapy: innovative strategies and clinical translation
W Wang, MC Lopez McDonald, R Hariprasad… - Cancers, 2024 - mdpi.com
Simple Summary Cancer is the second leading cause of death worldwide, accounting for
nearly one in six deaths. One of the key underlying factors distinguishing a cancer cell from …
nearly one in six deaths. One of the key underlying factors distinguishing a cancer cell from …
[HTML][HTML] Identification of the shared genetic architecture underlying seven autoimmune diseases with GWAS summary statistics
Y Wang, Y Yang, X Jia, C Zhao, C Yang, J Fan… - Frontiers in …, 2024 - frontiersin.org
Background The common clinical symptoms and immunopathological mechanisms have
been observed among multiple autoimmune diseases (ADs), but the shared genetic etiology …
been observed among multiple autoimmune diseases (ADs), but the shared genetic etiology …
[HTML][HTML] Pervasive Sharing of Causal Genetic Risk Factors Contributes to Clinical and Molecular Overlap between Sjögren's Disease and Systemic Lupus …
K Chau, Y Raksadawan, K Allison, JA Ice… - International Journal of …, 2023 - mdpi.com
SjD (Sjögren's Disease) and SLE (Systemic Lupus Erythematosus) are similar diseases.
There is extensive overlap between the two in terms of both clinical features and …
There is extensive overlap between the two in terms of both clinical features and …
Shared Genetic Architecture Contributes to Risk of Major Cardiovascular Diseases
S Pauklin, J Qiao, L Cai, M Chang, C Wang, R Zhao… - 2023 - researchsquare.com
The extensive co-occurrence of cardiovascular diseases (CVDs), as evidenced by
epidemiological studies, aligns with positive genetic correlations identified in …
epidemiological studies, aligns with positive genetic correlations identified in …