Most drugs, with few notable exceptions, such as heparin, exert their effects not within the
plasma compartment but in defined target tissues into which drugs must be distributed from …

Most drugs, with few notable exceptions, such as heparin, exert their effects not within the
plasma compartment but in defined target tissues into which drugs must be distributed from …

Liquid extraction surface analysis mass spectrometry (LESA‐MS) is a novel surface profiling
technique that combines micro‐liquid extraction from a solid surface with nano‐electrospray …

A simple method for the quantitation of 14 C-whole-body autoradiograms by comparative
densitometry is described. If processed under the same conditions as the samples of tissues …

Over the past decades, it has become abundantly clear that enzymes evolved to detoxify
and eliminate foreign chemicals from the body, occasionally generate highly reactive …

A novel method is described for quantitative whole-body autoradioluminography using [14C]-
radioactive standards prepared from rat red blood cells. MicroComputer Imaging Device …

Dr. Jose A. Valciukas, in Foundations of Environmental and Occupational Neurotoxicology,
has written a thorough, lively, and educational study on toxic substances and their effects …

The objective of this study was to demonstrate that tissue concentrations of radioactivity
derived by digital analysis of autoradiograms were comparable to values derived from direct …

Whole-body autoradiography (WBA) is a technique that has been available for many years
for studying the biological fate of chemicals. This technique, which is most frequently …

Light microscopy continues to represent the major method by which nephropathies are
identified in chemical safety assessment 1 and in the clinical situation 2. While ultrastructural …