The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

J Zeng, T Bao, K Yang, X Zhu, S Wang… - Frontiers in …, 2023 - frontiersin.org
Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and
oxidative stress play important roles in various complex mechanisms of IS. In particular, the …

The role of oxidative stress in acute ischemic stroke‐related thrombosis

Z Li, R Bi, S Sun, S Chen, J Chen… - Oxidative Medicine and …, 2022 - Wiley Online Library
Acute ischemic stroke is a serious life‐threatening disease that affects almost 600 million
people each year throughout the world with a mortality of more than 10%, while two‐thirds of …

Deciphering the catalytic mechanism of superoxide dismutase activity of carbon dot nanozyme

W Gao, J He, L Chen, X Meng, Y Ma, L Cheng… - Nature …, 2023 - nature.com
Nanozymes with superoxide dismutase (SOD)-like activity have attracted increasing interest
due to their ability to scavenge superoxide anion, the origin of most reactive oxygen species …

The Nrf2 pathway in ischemic stroke: a review

M Farina, LE Vieira, B Buttari, E Profumo, L Saso - Molecules, 2021 - mdpi.com
Ischemic stroke, characterized by the sudden loss of blood flow in specific area (s) of the
brain, is the leading cause of permanent disability and is among the leading causes of death …

A systematic review of the research progress of non-coding RNA in neuroinflammation and immune regulation in cerebral infarction/ischemia-reperfusion injury

K Yang, L Zeng, A Ge, S Wang, J Zeng, X Yuan… - Frontiers in …, 2022 - frontiersin.org
Cerebral infarction/ischemia-reperfusion injury is currently the disease with the highest
mortality and disability rate of cardiovascular disease. Current studies have shown that …

[HTML][HTML] The mechanism of ferroptosis regulating oxidative stress in ischemic stroke and the regulation mechanism of natural pharmacological active components

K Yang, L Zeng, X Yuan, S Wang, A Ge, H Xu… - Biomedicine & …, 2022 - Elsevier
Cerebrovascular diseases, such as ischemic stroke, pose serious medical challenges
worldwide due to their high morbidity and mortality and limitations in clinical treatment …

Geraniin protects against cerebral ischemia/reperfusion injury by suppressing oxidative stress and neuronal apoptosis via regulation of the Nrf2/HO‐1 pathway

Y Yang, B He, X Zhang, R Yang, X Xia… - Oxidative medicine …, 2022 - Wiley Online Library
Geraniin, a polyphenol isolated from Phyllanthus amarus, possesses extensive biological
and pharmaceutical activities. In this study, we investigated the protective effect against …

A Bioinspired Manganese‐Organic Framework Ameliorates Ischemic Stroke through its Intrinsic Nanozyme Activity and Upregulating Endogenous Antioxidant …

J Wang, Y Wang, X Xiaohalati, Q Su, J Liu… - Advanced …, 2023 - Wiley Online Library
Following stroke, oxidative stress induced by reactive oxygen species (ROS) aggravates
neuronal damage and enlarges ischemic penumbra, which is devastating to stroke patients …

[HTML][HTML] The role of mitochondrial dynamics in cerebral ischemia-reperfusion injury

J Huang, L Chen, Z Yao, X Sun, X Tong… - Biomedicine & …, 2023 - Elsevier
Stroke is one of the leading causes of death and long-term disability worldwide. More than
80% of strokes are ischemic, caused by an occlusion of cerebral arteries. Without question …

Neuroprotective function of high glycolytic activity in astrocytes: common roles in stroke and neurodegenerative diseases

S Takahashi - International Journal of Molecular Sciences, 2021 - mdpi.com
Astrocytes (also, astroglia) consume huge amounts of glucose and produce lactate
regardless of sufficient oxygen availability, indicating a high capacity for aerobic glycolysis …