Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential
Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …
Minocycline: far beyond an antibiotic
N Garrido‐Mesa, A Zarzuelo… - British journal of …, 2013 - Wiley Online Library
Minocycline is a second‐generation, semi‐synthetic tetracycline that has been in therapeutic
use for over 30 years because of its antibiotic properties against both gram‐positive and …
use for over 30 years because of its antibiotic properties against both gram‐positive and …
Physiology of microglia
H Kettenmann, UK Hanisch, M Noda… - Physiological …, 2011 - journals.physiology.org
Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …
The effect of pain on cognitive function: a review of clinical and preclinical research
O Moriarty, BE McGuire, DP Finn - Progress in neurobiology, 2011 - Elsevier
Cognitive impairment is commonly associated with the pain experience. This impairment
represents a major obstacle to daily activities and rehabilitation, especially in the chronic …
represents a major obstacle to daily activities and rehabilitation, especially in the chronic …
Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord
Previous studies have shown that activation of p38 mitogen-activating kinase (MAPK) in
spinal microglia participates in the generation of inflammatory and neuropathic pain in …
spinal microglia participates in the generation of inflammatory and neuropathic pain in …
[HTML][HTML] Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury
Microglia and peripheral monocytes contribute to hypersensitivity in rodent models of
neuropathic pain. However, the precise respective function of microglia and peripheral …
neuropathic pain. However, the precise respective function of microglia and peripheral …
Neuropeptides and microglial activation in inflammation, pain, and neurodegenerative diseases
L Carniglia, D Ramírez, D Durand… - Mediators of …, 2017 - Wiley Online Library
Microglial cells are responsible for immune surveillance within the CNS. They respond to
noxious stimuli by releasing inflammatory mediators and mounting an effective inflammatory …
noxious stimuli by releasing inflammatory mediators and mounting an effective inflammatory …
Microglia: biology and pathology
MB Graeber, WJ Streit - Acta neuropathologica, 2010 - Springer
The past 20 years have seen a gain in knowledge on microglia biology and microglia
functions in disease that exceeds the expectations formulated when the microglia “immune …
functions in disease that exceeds the expectations formulated when the microglia “immune …
Chemokines, neuronal–glial interactions, and central processing of neuropathic pain
Millions of people worldwide suffer from neuropathic pain as a result of damage to or
dysfunction of the nervous system under various disease conditions. Development of …
dysfunction of the nervous system under various disease conditions. Development of …
[HTML][HTML] IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype
Microglia become activated by multiple types of damage in the nervous system and play
essential roles in neuronal pathologies. However, how microglia transform into reactive …
essential roles in neuronal pathologies. However, how microglia transform into reactive …