The relative importance of the intrinsic and extrinsic apoptotic pathways in the control of
haematopoietic cell homeostasis has been a matter of debate for many years. Cell death is …

Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal hyperinflammatory
syndrome with prolonged high fever, hepatosplenomegaly and characteristic laboratory …

The failure of CD8+ T cells to respond to chronic infection has been termed “exhaustion” and
describes the condition in which CD8+ T cells exhibit reduced differentiation, proliferation …

While antigen-primed T cells proliferate at speeds close to the physiologic maximum of
mammalian cells, T cell memory is maintained in the absence of antigen by rare cell …

Throughout most of adult life, lymphocyte number remains constant because of a balance of
proliferation and apoptosis. Mutation of Bim, a proapoptotic protein in the intrinsic death …

Interferons (IFNs) type‐1 (IFN α/β) and type‐II (IFN‐γ) are the most pleiotropic molecules in
the intricate cytokine network. This dominance arises from three crucial factors:(i) initiation of …

Apoptosis plays an essential role in T cell biology. Thymocytes expressing nonfunctional or
autoreactive TCRs are eliminated by apoptosis during development. Apoptosis also leads to …

Infection with Listeria monocytogenes strains that enter the host cell cytosol leads to a robust
cytotoxic T cell response resulting in long-lived cell-mediated immunity (CMI). Upon entry …

Activated CD8+ T cells choose between terminal effector cell (TEC) or memory precursor
cell (MPC) fates. We found that the signaling receptor Notch controls this' choice'. Notch …

The activation and differentiation of CD8 T cells is a necessary first step that endows these
cells with the phenotypic and functional properties required for the control of intracellular …