Real-world adherence and persistence to direct oral anticoagulants in patients with atrial fibrillation: a systematic review and meta-analysis

AF Ozaki, AS Choi, QT Le, DT Ko, JK Han… - … Quality and Outcomes, 2020 - Am Heart Assoc
Background: Stroke reduction with direct oral anticoagulants (DOACs) in atrial fibrillation
(AF) is dependent on adherence and persistence in the real-world setting. Individual study …

Towards better reporting of the proportion of days covered method in cardiovascular medication adherence: A scoping review and new tool TEN‐SPIDERS

LL Dalli, MF Kilkenny, I Arnet… - British Journal of …, 2022 - Wiley Online Library
Although medication adherence is commonly measured in electronic datasets using the
proportion of days covered (PDC), no standardized approach is used to calculate and report …

Association of oral anticoagulants and verapamil or diltiazem with adverse bleeding events in patients with nonvalvular atrial fibrillation and normal kidney function

P Pham, S Schmidt, L Lesko, GYH Lip… - JAMA network …, 2020 - jamanetwork.com
Importance Direct oral anticoagulants (DOACs) are purported to have fewer drug-drug
interactions than warfarin. However, potential interactions with coprescribed medications are …

Non-warfarin oral anticoagulant copayments and adherence in atrial fibrillation: a population-based cohort study

BN Rome, JJ Gagne, J Avorn, AS Kesselheim - American Heart Journal, 2021 - Elsevier
Background In patients with atrial fibrillation, incomplete adherence to anticoagulants
increases risk of stroke. Non-warfarin oral anticoagulants (NOACs) are expensive; we …

Time trends and treatment pathways in prescribing individual oral anticoagulants in patients with nonvalvular atrial fibrillation: an observational study of more than …

P Vora, H Morgan Stewart, B Russell… - … journal of clinical …, 2022 - Wiley Online Library
Background. Data directly comparing trends in the use of different oral anticoagulants
(OACs) among patients with atrial fibrillation (AF) from different countries are limited. We …

Factors associated with primary nonadherence to newly initiated direct oral anticoagulants in patients with nonvalvular atrial fibrillation

A Charlton, X Vidal, M Sabaté, E Bailarín… - Journal of managed …, 2021 - jmcp.org
BACKGROUND: Direct oral anticoagulants (DOACs) are widely used for the prevention of
stroke in nonvalvular atrial fibrillation (NVAF); however, real-world primary nonadherence …

Real-world adherence for direct oral anticoagulants in a newly diagnosed atrial fibrillation cohort: does the dosing interval matter?

PN Pham, JD Brown - BMC Cardiovascular Disorders, 2019 - Springer
Background Differences in adherence may represent drug properties (eg dosing interval) or
patient experiences while on treatment. Adherence to direct oral anticoagulants (DOACs) in …

Patients' and clinicians' perceptions of oral anticoagulants in atrial fibrillation: a systematic narrative review and meta-analysis

YM Osasu, R Cooper, C Mitchell - BMC family practice, 2021 - Springer
Background Atrial fibrillation (AF) increases the risk of developing a stroke by 20%. AF
related strokes are associated with greater morbidity. Historically, warfarin was the …

Estimating adherence based on prescription or dispensation information: impact on thresholds and outcomes. A real-world study with atrial fibrillation patients treated …

I Hurtado-Navarro, A García-Sempere… - Frontiers in …, 2018 - frontiersin.org
Objective: To estimate drug exposure, Proportion of Days Covered (PDC) and percentage of
patients with PDC≥ 80% from a cohort of atrial fibrillation patients initiating oral …

[HTML][HTML] Reducing stroke risk in atrial fibrillation: adherence to guidelines has improved, but patient persistence with anticoagulant therapy remains suboptimal

N Lowres, K Giskes, C Hespe… - Korean Circulation …, 2019 - synapse.koreamed.org
Atrial fibrillation (AF) is a significant risk factor for avoidable stroke. Among high-risk patients
with AF, stroke risk can be mitigated using oral anticoagulants (OACs), however reduction is …