The gut microbiota shows a wide inter-individual variation, but its within-individual variation
is relatively stable over time. A functional core microbiome, provided by abundant bacterial …

ABSTRACT A major challenge in the biology of aging is to understand how specific age-
onset pathologies relate to the overall health of the organism. The integrity of the intestinal …

The FDA approved drug rapamycin can prolong lifespan in diverse species and delay the
onset of age-related disease in mammals. However, a number of fundamental questions …

Studies in mammals, including humans, have reported age-related changes in microbiota
dynamics. A major challenge, however, is to dissect the cause and effect relationships …

The innate immune response tends to become hyperactive and proinflammatory in older
organisms. We investigated connections between activity of the immune‐related genes and …

Autophagy ensures the lysosome-mediated breakdown and recycling of self-material, as it
not only degrades obsolete or damaged intracellular constituents but also provides building …

The effects of aging on the brain are widespread and can have dramatic implications on the
overall health of an organism. Mitochondrial dysfunction is a hallmark of brain aging, but the …

Intestinal barrier dysfunction is an evolutionarily conserved hallmark of aging, which has
been linked to microbial dysbiosis, altered expression of occluding junction proteins, and …

Epithelial immunity protects the host from harmful microbial invaders but also controls the
beneficial microbiota on epithelial surfaces. When this delicate balance between pathogen …

Mammals develop age-associated clonal expansion of somatic mtDNA mutations resulting
in severe respiratory chain deficiency in a subset of cells in a variety of tissues. Both …