Female sex is a leading risk factor for developing Alzheimer's disease (AD). Sexual
dimorphism in AD is gaining attention as clinical data show that women are not only more …

Abstract Background Approximately 70% of Alzheimer's disease (AD) patients have co-
morbid vascular contributions to cognitive impairment and dementia (VCID); this highly …

Olfactory dysfunction is considered a pre-cognitive biomarker of Alzheimer's disease (AD).
Because the olfactory system is highly conserved across species, mouse models …

Now astrocytes appear to be the key contributors to the pathophysiology of major
depression. Evidence in rodents shows that chronic stress is associated with a decreased …

Research on Alzheimer's disease (AD) has classically focused on alterations that occur in
the brain and their intra-and extracellular neuropathological hallmarks. However, the oxi …

Macrophages and microglia are highly versatile cells that can be polarized into M1 and M2
phenotypes in response to diverse environmental stimuli, thus exhibiting different biological …

Longitudinal approaches for disease-monitoring in old animals face survival and frailty
limitations, but also assessment and re-test bias on genotype and sex effects. The present …

The prevalence of Alzheimer's disorder (AD) is increasing worldwide, and the co-morbid
anxiety is an important, albeit often neglected problem, which might appear early during …

Dementia remains one of the leading causes of morbidity and mortality in older adults.
Alzheimer's disease (AD) is the most common type of dementia, affecting over 55 million …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common form of dementia. Approximately 50% of AD patients show anxiety and depressive …