Type 1 diabetes affects millions of people globally and requires careful management to
avoid serious long-term complications, including heart and kidney disease, stroke, and loss …

Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the
immune system. Despite improvements in insulin analogs and continuous blood glucose …

Impaired function of pancreatic islet cells is a major cause of metabolic dysregulation and
disease in humans. Despite this, it remains challenging to directly link physiological …

Multiple biologically active components of human milk support infant growth, health and
development. Milk provides a wide spectrum of mammary epithelial cell-derived …

Diabetes mellitus, which affects more than 463 million people globally, is caused by the
autoimmune ablation or functional loss of insulin-producing β-cells, and prevalence is …

Successful strategies for treating type 1 diabetes need to restore the function of pancreatic
beta cells that are destroyed by the immune system and overcome further destruction of …

Many patients with type 1 diabetes (T1D) have residual β cells producing small amounts of
C-peptide long after disease onset but develop an inadequate glucagon response to …

The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …

Findings from the past 10 years have placed the glucagon-secreting pancreatic α-cell centre
stage in the development of diabetes mellitus, a disease affecting almost one in every ten …

Type 2 diabetes is a disease involving both inadequate insulin levels and increased
glucagon levels. While glucagon and insulin work together to achieve optimal plasma …