Organ fibrosis is characterized by the accumulation of disorganized and stiff extracellular
matrix (ECM) and represents the final stage of several life-threatening diseases. The …

Matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinases (ADAMs)
belong to the metzincin family of zinc-containing multidomain molecules, and can act as …

Around the world diabetic kidney disease (DKD) is the main cause of chronic kidney disease
(CKD), which is characterized by mesangial expansion, glomerulosclerosis, tubular atrophy …

Autophagy is a cell self-renewal process that relies on the degradation of the cytoplasmic
proteins or organelles of lysosomes and is associated with development of numerous …

Natural extracellular matrices (ECM) are currently being studied as an alternative source for
organ transplantation or as new solutions to treat kidney injuries, which can evolve to end …

Tissue remodeling is broadly defined as the reorganization or restoration of existing tissues.
Tissue remodeling processes are responsible for directing the development and …

Chronic Kidney Disease (CKD) represents a risk factor for fatal and nonfatal cardiovascular
(CV) events, including peripheral vascular disease (PVD). This occurs because CKD …

In this study, we examined the effect of MC1568, a selective class IIa histone deacetylase
(HDAC) inhibitor, on the development and progression of renal fibrosis in a murine model of …

Abstract Ethnopharmacological relevance In China, Xanthoceras sorbifolium Bunge was first
documented as “Wen Guan Hua” in the “Jiu Huang Ben Cao” in 1406 AD According to the …

Chronic kidney disease (CKD) is a major health problem, affecting millions of people
worldwide, in particular hypertensive and diabetic patients. CKD patients suffer from …