Therapeutic approaches to control tissue repair and fibrosis: Extracellular matrix as a game changer
M Walraven, B Hinz - Matrix Biology, 2018 - Elsevier
Organ fibrosis is characterized by the accumulation of disorganized and stiff extracellular
matrix (ECM) and represents the final stage of several life-threatening diseases. The …
matrix (ECM) and represents the final stage of several life-threatening diseases. The …
Key metalloproteinase-mediated pathways in the kidney
J Wozniak, J Floege, T Ostendorf… - Nature Reviews …, 2021 - nature.com
Matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinases (ADAMs)
belong to the metzincin family of zinc-containing multidomain molecules, and can act as …
belong to the metzincin family of zinc-containing multidomain molecules, and can act as …
[HTML][HTML] Matrix metalloproteinases in diabetic kidney disease
N Garcia-Fernandez, C Jacobs-Cachá… - Journal of clinical …, 2020 - mdpi.com
Around the world diabetic kidney disease (DKD) is the main cause of chronic kidney disease
(CKD), which is characterized by mesangial expansion, glomerulosclerosis, tubular atrophy …
(CKD), which is characterized by mesangial expansion, glomerulosclerosis, tubular atrophy …
[HTML][HTML] Delayed treatment with an autophagy inhibitor 3-MA alleviates the progression of hyperuricemic nephropathy
Y Shi, M Tao, X Ma, Y Hu, G Huang, A Qiu… - Cell Death & …, 2020 - nature.com
Autophagy is a cell self-renewal process that relies on the degradation of the cytoplasmic
proteins or organelles of lysosomes and is associated with development of numerous …
proteins or organelles of lysosomes and is associated with development of numerous …
Renal regeneration: the role of extracellular matrix and current ECM‐based tissue engineered strategies
R Sobreiro‐Almeida, R Quinteira… - Advanced healthcare …, 2021 - Wiley Online Library
Natural extracellular matrices (ECM) are currently being studied as an alternative source for
organ transplantation or as new solutions to treat kidney injuries, which can evolve to end …
organ transplantation or as new solutions to treat kidney injuries, which can evolve to end …
[HTML][HTML] Mechanisms of physiological tissue remodeling in animals: Manipulating tissue, organ, and organism morphology
K Pinet, KA McLaughlin - Developmental biology, 2019 - Elsevier
Tissue remodeling is broadly defined as the reorganization or restoration of existing tissues.
Tissue remodeling processes are responsible for directing the development and …
Tissue remodeling processes are responsible for directing the development and …
[HTML][HTML] The association of matrix metalloproteinases with chronic kidney disease and peripheral vascular disease: a light at the end of the tunnel?
M Provenzano, M Andreucci, C Garofalo, T Faga… - Biomolecules, 2020 - mdpi.com
Chronic Kidney Disease (CKD) represents a risk factor for fatal and nonfatal cardiovascular
(CV) events, including peripheral vascular disease (PVD). This occurs because CKD …
(CV) events, including peripheral vascular disease (PVD). This occurs because CKD …
[HTML][HTML] Selective inhibition of class IIa histone deacetylases alleviates renal fibrosis
In this study, we examined the effect of MC1568, a selective class IIa histone deacetylase
(HDAC) inhibitor, on the development and progression of renal fibrosis in a murine model of …
(HDAC) inhibitor, on the development and progression of renal fibrosis in a murine model of …
Xanthoceras sorbifolium leaves alleviate hyperuricemic nephropathy by inhibiting the PI3K/AKT signaling pathway to regulate uric acid transport
Y Liu, Y Han, Y Liu, C Huang, W Feng, H Cui… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance In China, Xanthoceras sorbifolium Bunge was first
documented as “Wen Guan Hua” in the “Jiu Huang Ben Cao” in 1406 AD According to the …
documented as “Wen Guan Hua” in the “Jiu Huang Ben Cao” in 1406 AD According to the …
[HTML][HTML] ADAM10 and ADAM17, major regulators of chronic kidney disease induced atherosclerosis?
SL Maas, MMPC Donners… - International journal of …, 2023 - mdpi.com
Chronic kidney disease (CKD) is a major health problem, affecting millions of people
worldwide, in particular hypertensive and diabetic patients. CKD patients suffer from …
worldwide, in particular hypertensive and diabetic patients. CKD patients suffer from …