Redox homeostasis is a delicate balancing act of maintaining appropriate levels of
antioxidant defense mechanisms and reactive oxidizing oxygen and nitrogen species. Any …

With the global prevalence of diabetes mellitus over recent decades, more patients suffered
from various diabetic complications, including diabetic ocular surface diseases that may …

The transparency of the cornea along with its dense sensory innervation and resident
leukocyte populations make it an ideal tissue to study interactions between the nervous and …

Calcitonin gene-related peptide (CGRP) is a multifunctional neuropeptide abundantly
expressed by corneal nerves. Using a murine model of corneal mechanical injury, we found …

Diabetes mellitus, the most prevalent endocrine disorder, not only impacts the retina but also
significantly involves the ocular surface. Diabetes contributes to the development of dry eye …

The healthy human cornea is a uniquely transparent sensory tissue where immune
responses are tightly controlled to preserve vision. The cornea contains immune cells that …

Delayed or prolonged corneal wound healing and non-healing corneas put patients at risk
for ocular surface infections and subsequent stromal opacification, resulting in discomfort or …

Diabetes mellitus is a global public health problem with both macrovascular and
microvascular complications, such as diabetic corneal neuropathy (DCN). Using in-vivo …

Corneal nerve homeostasis is essential for the functional integrity of the ocular surface.
Vitamin D deficiency (VDD) and vitamin D receptor knockout (VDR KO) have been found to …

Homeostatic maintenance is essential for pulp function. Disrupting pulp homeostasis may
lead to pulp degeneration, such as fibrosis and calcifications. Sensory nerves constitute a …