Genetics, genomics, and cancer risk assessment: state of the art and future directions in the era of personalized medicine
JN Weitzel, KR Blazer, DJ MacDonald… - CA: a cancer journal …, 2011 - Wiley Online Library
Scientific and technologic advances are revolutionizing our approach to genetic cancer risk
assessment, cancer screening and prevention, and targeted therapy, fulfilling the promise of …
assessment, cancer screening and prevention, and targeted therapy, fulfilling the promise of …
Genetic Risk Assessment and BRCA Mutation Testing for Breast and Ovarian Cancer Susceptibility: Systematic Evidence Review for the US Preventive Services Task …
Background: Clinically significant mutations of BRCA1 and BRCA2 genes are associated
with increased susceptibility for breast and ovarian cancer. Although these mutations are …
with increased susceptibility for breast and ovarian cancer. Although these mutations are …
[HTML][HTML] Family history and risk of breast cancer: an analysis accounting for family structure
HR Brewer, ME Jones, MJ Schoemaker… - Breast cancer research …, 2017 - Springer
Purpose Family history is an important risk factor for breast cancer incidence, but the
parameters conventionally used to categorize it are based solely on numbers and/or ages of …
parameters conventionally used to categorize it are based solely on numbers and/or ages of …
Risk of pancreatic cancer in families with Lynch syndrome
Context Lynch syndrome is an inherited cause of colorectal cancer caused by mutations of
DNA mismatch repair (MMR) genes. A number of extracolonic tumors have been associated …
DNA mismatch repair (MMR) genes. A number of extracolonic tumors have been associated …
Calculation of risk of colorectal and endometrial cancer among patients with Lynch syndrome
E Stoffel, B Mukherjee, VM Raymond, N Tayob… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: Lynch syndrome is the most common hereditary colorectal cancer
(CRC) syndrome. Some previous estimates of lifetime risk for CRC and endometrial cancer …
(CRC) syndrome. Some previous estimates of lifetime risk for CRC and endometrial cancer …
Genetic/familial high-risk assessment: breast and ovarian
MB Daly, JE Axilbund, S Buys, B Crawford… - Journal of the National …, 2010 - jnccn.org
All cancers develop as a result of mutations in certain genes, such as those involved in the
regulation of cell growth and/or DNA repair, 1, 2 but not all of these mutations are inherited …
regulation of cell growth and/or DNA repair, 1, 2 but not all of these mutations are inherited …
Concise handbook of familial cancer susceptibility syndromes
NM Lindor, ML McMaster, CJ Lindor… - Journal of the National …, 2008 - academic.oup.com
More than 10 years have passed since we first attempted to develop a clinically accessible
catalog of recognizable family cancer syndromes (1). Our sense at that time was that we …
catalog of recognizable family cancer syndromes (1). Our sense at that time was that we …
Family history and risk of breast cancer: nurses' health study
GA Colditz, KA Kaphingst, SE Hankinson… - Breast cancer research …, 2012 - Springer
Family history of cancer remains underused in general clinical practice. We assess age at
diagnosis and the role of family history in risk of breast cancer. Prospective follow-up of …
diagnosis and the role of family history in risk of breast cancer. Prospective follow-up of …
[HTML][HTML] Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
Cancers harbor many somatic mutations and germline variants, we hypothesized that the
combined effect of germline variants that alter the structure, expression, or function of protein …
combined effect of germline variants that alter the structure, expression, or function of protein …
Family history in public health practice: a genomic tool for disease prevention and health promotion
R Valdez, PW Yoon, N Qureshi… - Annual review of …, 2010 - annualreviews.org
Family history is a risk factor for many chronic diseases, including cancer, cardiovascular
disease, and diabetes. Professional guidelines usually include family history to assess …
disease, and diabetes. Professional guidelines usually include family history to assess …