Scientific and technologic advances are revolutionizing our approach to genetic cancer risk
assessment, cancer screening and prevention, and targeted therapy, fulfilling the promise of …

Background: Clinically significant mutations of BRCA1 and BRCA2 genes are associated
with increased susceptibility for breast and ovarian cancer. Although these mutations are …

Purpose Family history is an important risk factor for breast cancer incidence, but the
parameters conventionally used to categorize it are based solely on numbers and/or ages of …

Context Lynch syndrome is an inherited cause of colorectal cancer caused by mutations of
DNA mismatch repair (MMR) genes. A number of extracolonic tumors have been associated …

BACKGROUND & AIMS: Lynch syndrome is the most common hereditary colorectal cancer
(CRC) syndrome. Some previous estimates of lifetime risk for CRC and endometrial cancer …

All cancers develop as a result of mutations in certain genes, such as those involved in the
regulation of cell growth and/or DNA repair, 1, 2 but not all of these mutations are inherited …

More than 10 years have passed since we first attempted to develop a clinically accessible
catalog of recognizable family cancer syndromes (1). Our sense at that time was that we …

Family history of cancer remains underused in general clinical practice. We assess age at
diagnosis and the role of family history in risk of breast cancer. Prospective follow-up of …

Cancers harbor many somatic mutations and germline variants, we hypothesized that the
combined effect of germline variants that alter the structure, expression, or function of protein …

Family history is a risk factor for many chronic diseases, including cancer, cardiovascular
disease, and diabetes. Professional guidelines usually include family history to assess …