Purpose: To our knowledge the reasons for the high rates of prostate cancer in black
American men are unknown. Genetic and lifestyle factors have been implicated. Better …

Background Many studies on prostate cancer (PCa) germline variants have been published
in the last 15 years. This review critically assesses their clinical validity and explores their …

Renal cell carcinoma (RCC) represents between 80 and 90% of kidney cancers. Previous
genome-wide association studies of RCC have identified five variants conferring risk of the …

Most cancer-associated single-nucleotide polymorphisms (SNP) identified using genome-
wide association studies are located outside of protein-coding regions, and their …

Bladder cancer is an excellent model for studying genetic susceptibility and gene–
environment interaction in cancer etiology. The candidate gene approach found NAT2 slow …

Circulating cell‐free DNA has been recognized as an accurate marker for the diagnosis of
prostate cancer, whereas the role of urine cell‐free DNA (UCF DNA) has never been …

Abstract Since 2007, genome-wide association (GWA) studies have identified numerous
well-supported, novel genetic risk loci for common cancers; however, there are concerns …

Prostate cancer (PCa) is the second leading cause of cancer-related deaths in the United
States. The African (AA) descent has greater incidence and mortality rates of PCa as …

Abstract Post-Human Genome Project progress has enabled a new wave of population
genetic research, and intensified controversy over the use of race/ethnicity in this work. At …

The testes are where spermatogenesis, the sperm‐generating process that is unique to
men, occurs. Importantly, human spermatogenesis and tumorigenesis share key similarities …