Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives

JS Bhatti, A Sehrawat, J Mishra, IS Sidhu… - Free Radical Biology …, 2022 - Elsevier
Abstract Type 2 diabetes (T2DM) is a persistent metabolic disorder rising rapidly worldwide.
It is characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia …

[HTML][HTML] The key role of mitochondrial function in health and disease

I San-Millán - Antioxidants, 2023 - mdpi.com
The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …

[HTML][HTML] Mitochondrial dysfunction and oxidative stress in metabolic disorders—A step towards mitochondria based therapeutic strategies

JS Bhatti, GK Bhatti, PH Reddy - … et Biophysica Acta (BBA)-Molecular Basis …, 2017 - Elsevier
Mitochondria are the powerhouses of the cell and are involved in essential functions of the
cell, including ATP production, intracellular Ca 2+ regulation, reactive oxygen species …

[HTML][HTML] Metabolic syndrome: risk factors, diagnosis, pathogenesis, and management with natural approaches

SM Mohamed, MA Shalaby, RA El-Shiekh… - Food Chemistry …, 2023 - Elsevier
Metabolic syndrome (MetS) is a bunch of metabolic defects comprising hypertension, insulin
resistance, visceral obesity, fatty liver, and atherogenic cardiovascular diseases. Lifestyle …

Healthful aging mediated by inhibition of oxidative stress

SF Vatner, J Zhang, M Oydanich, T Berkman… - Ageing Research …, 2020 - Elsevier
The progressive increase in lifespan over the past century carries with it some adversity
related to the accompanying burden of debilitating diseases prevalent in the older …

[HTML][HTML] Quercetin as an agent for protecting the bone: a review of the current evidence

SK Wong, KY Chin, S Ima-Nirwana - International journal of molecular …, 2020 - mdpi.com
Quercetin is a flavonoid abundantly found in fruits and vegetables. It possesses a wide
spectrum of biological activities, thus suggesting a role in disease prevention and health …

Biomarkers of oxidative stress in metabolic syndrome and associated diseases

R Vona, L Gambardella, C Cittadini… - Oxidative medicine …, 2019 - Wiley Online Library
Metabolic syndrome (MS) represents worldwide public health issue characterized by a set of
cardiovascular risk factors including obesity, diabetes, dyslipidemia, hypertension, and …

Redox-and non-redox-metal-induced formation of free radicals and their role in human disease

M Valko, K Jomova, CJ Rhodes, K Kuča… - Archives of toxicology, 2016 - Springer
Transition metal ions are key elements of various biological processes ranging from oxygen
formation to hypoxia sensing, and therefore, their homeostasis is maintained within strict …

Mitochondrial dysfunction in obesity

AH de Mello, AB Costa, JDG Engel, GT Rezin - Life sciences, 2018 - Elsevier
Obesity leads to various changes in the body. Among them, the existing inflammatory
process may lead to an increase in the production of reactive oxygen species (ROS) and …

[HTML][HTML] Metabolic syndrome, aging and involvement of oxidative stress

F Bonomini, LF Rodella, R Rezzani - Aging and disease, 2015 - ncbi.nlm.nih.gov
The prevalence of the metabolic syndrome, a cluster of cardiovascular risk factors
associated with obesity and insulin resistance, is dramatically increasing in Western and …