KSR1 knockout mouse model demonstrates MAPK pathway's key role in cisplatin-and noise-induced hearing loss

MA Ingersoll, RD Lutze, RG Kelmann… - Journal of …, 2024 - Soc Neuroscience
Hearing loss is a major disability in everyday life and therapeutic interventions to protect
hearing would benefit a large portion of the world population. Here we found that mice …

[HTML][HTML] Oseltamivir (Tamiflu), a commonly prescribed antiviral drug, mitigates hearing loss in mice

EJ Sailor‐Longsworth, RD Lutze… - Clinical and …, 2024 - ncbi.nlm.nih.gov
Dear Editor, Hearing loss affects up to 10% of people worldwide and therapeutic
interventions are desperately needed. Noise exposure and chemotherapy treatments are …

Trametinib, a MEK1/2 Inhibitor, Protects Mice from Cisplatin-and Noise-Induced Hearing Loss

RD Lutze, MA Ingersoll, RG Kelmann, T Teitz - Pharmaceuticals, 2024 - mdpi.com
Hearing loss is one of the most common types of disability; however, there is only one FDA-
approved drug to prevent any type of hearing loss. Treatment with the highly effective …

FDA-Approved MEK1/2 Inhibitor, Trametinib, Protects Mice from Cisplatin and Noise-Induced Hearing Loss

RD Lutze, MA Ingersoll, RG Kelmann, T Teitz - bioRxiv, 2024 - biorxiv.org
Hearing loss is one of the most common types of disability; however, there is only one FDA-
approved drug to prevent any type of hearing loss. Treatment with the highly effective …