Introduction: Hypertension is caused by increased cardiac output and/or increased
peripheral resistance. Areas covered: The various mechanisms affecting cardiac …

Climie et al Macrovasculature and Microvasculature in HTN and T2D 1139 million global
disability-adjusted life years, an increase of 11.7% from 2005. 9 Because hypertension …

Tempol is a redox-cycling nitroxide that promotes the metabolism of many reactive oxygen
species (ROS) and improves nitric oxide bioavailability. It has been studied extensively in …

Insulin resistance and hypertension are considered as prototypical “diseases of civilization”
that are manifested in the modern environment as plentiful food and sedentary life. The …

The incidence of metabolic syndrome is rapidly increasing in the United States and
worldwide. The metabolic syndrome is a complex metabolic and vascular disorder that is …

Salt sensitivity of blood pressure (SSBP) is an independent risk factor for cardiovascular
morbidity and mortality that is seen in both hypertensive and normotensive populations …

Objectives Activation of the nuclear factor kappa B (NFκB) inflammatory pathway by
angiotensin II and reactive oxygen species may play an important role in the development of …

Metabolic actions of insulin to promote glucose disposal are augmented by nitric oxide (NO)-
dependent increases in microvascular blood flow to skeletal muscle. The balance between …

Background To determine whether the administration of angiotensin-converting enzyme
(ACE) inhibitors or angiotensin II receptor blockers (ARBs) on top of standard cardiovascular …

The prevalence of type 2 diabetes mellitus (T2DM) and its major risk factor, obesity, has
reached epidemic proportions in Western society. How obesity leads to insulin resistance …