Autism spectrum disorder (ASD) has a major impact on the development and social
integration of affected individuals and is the most heritable of psychiatric disorders. An …

The sophisticated circuitry of the neocortex is assembled from a diverse repertoire of
neuronal subtypes generated during development under precise molecular regulation. In …

Brain development and function depend on the precise regulation of gene expression.
However, our understanding of the complexity and dynamics of the transcriptome of the …

The neocortex is the part of the brain responsible for execution of higher-order brain
functions, including cognition, sensory perception, and sophisticated motor control. During …

The study of human cortical development has major implications for brain evolution and
diseases but has remained elusive due to paucity of experimental models. Here we found …

Directing the differentiation of induced pluripotent stem cells into motor neurons has allowed
investigators to develop new models of amyotrophic lateral sclerosis (ALS). However …

The corticospinal tract (CST) plays a major role in cortical control of spinal cord activity. In
particular, it is the principal motor pathway for voluntary movements. Here, we discuss:(i) the …

The procedure of neurogenesis has made numerous achievements in the past decades,
during which various molecular biomarkers have been emerging and have been broadly …

The cerebral neocortex is segregated into six horizontal layers, each containing unique
populations of molecularly and functionally distinct excitatory projection (pyramidal) neurons …

The abilities of stem cells to self-renew and form different mature cells expand the
possibilities of applications in cell-based therapies such as tissue recomposition in …