Acute Trypanosoma cruzi infections can be asymptomatic, but chronically infected
individuals can die of Chagas' disease. The transfer of the parasite mitochondrial kinetoplast …

1. Prologue 582. The Hodgkin–Huxley formalism for computing the action potential 592.1
The axon action potential model 592.2 Cardiac action potential models 623. Ion-channel …

Normal cardiac function requires an appropriate and regular beating rate (cardiac rhythm).
When the heart rhythm is too fast or too slow, cardiac function can be impaired, with …

Mutations in the cardiac ryanodine receptor 2 (RyR2) have been associated with
catecholaminergic polymorphic ventricular tachycardia and a form of arrhythmogenic right …

BACKGROUND: The mainstay of therapy for catecholaminergic polymorphic ventricular
tachycardia (CPVT) is maximal doses of β-blockers. However, although β-blockers prevent …

BACKGROUND: Mutations in the RyR2-encoded cardiac ryanodine receptor/calcium
release channel and in CASQ2-encoded calsequestrin cause catecholaminergic …

Functional assessments of cardiovascular fitness (CVF) are needed to establish animal
models of dysfunction, test the effects of novel therapeutics, and establish the cardio …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a familial condition that
presents with exercise‐induced syncope or sudden death in children or young adults. In …

Sudden cardiac death is a major public health problem affecting 500,000 patients annually
in the United States alone. The major risk factor for sudden cardiac death is the presence of …

Rationale: Mutations of the ryanodine receptor (RyR) cause catecholaminergic polymorphic
ventricular tachycardia (CPVT). These mutations predispose to the generation of Ca waves …