The congenital heart disease includes abnormalities in heart structure that occur before
birth. Such defects occur in the fetus while it is developing in the uterus during pregnancy …

Animal models of cardiovascular disease are key players in the translational medicine
pipeline used to define the conserved genetic and molecular basis of disease. Congenital …

In spite of improving life expectancy over the course of the previous century, the health of the
US population is now worsening. Recent increasing rates of type 2 diabetes, obesity and …

Embryonic heart development is an intricate process that mainly involves morphogens,
transcription factors, and cardiac genes. The precise spatiotemporal expression of these …

Myocardin is a muscle lineage–restricted transcriptional coactivator that has been shown to
transduce extracellular signals to the nucleus required for SMC differentiation. We now …

The majority of congenital heart defects (CHDs) are thought to result from the interaction
between multiple genetic, epigenetic, environmental, and lifestyle factors. Epigenetic …

The present study aimed to investigate genetic and environmental factors involved in the
pathogenesis of congenital heart disease (CHD). A total of 61 familial pedigrees with CHD …

STUDY QUESTION Is there an association between advanced paternal age and congenital
heart defects (CHD)? SUMMARY ANSWER Advanced paternal age is associated with a …

The prognosis of children with congenital heart defects (CHDs) continues to improve with
advancing surgical techniques; however, lack of information about modifiable risk factors for …

Programming with an insult or stimulus during critical developmental life stages shapes
metabolic disease through divergent mechanisms. Cardiovascular disease increasingly …