Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides
and nucleosides. Tri-and diphosphonucleotides are released in physiological and …

The oral mucosa is a site of intense immune activity, where a large variety of immune cells
meet to provide a first line of defense against pathogenic organisms. Interestingly, the oral …

SARS-CoV-2 is the cause of COVID-19. It infects multiple organs including the respiratory
tract and gut. Dynamic changes of regional microbiomes in infected adults are largely …

The oral cavity is the gateway for microorganisms into your body where they disseminate not
only to the directly connected respiratory and digestive tracts but also to the many remote …

The sharp increase in infections associated with multidrug-resistant (MDR) bacterial
pathogens that have seriously compromised traditional chemotherapeutics is becoming a …

Porphyromonas gingivalis and Filifactor alocis are fastidious oral pathogens and etiological
agents associated with chronic periodontitis. Although previous studies showed increased …

Epithelia are structurally integral elements in the fabric of oral mucosa with significant
functional roles. Similarly, the gingival epithelium performs uniquely critical tasks in …

Epithelial cells line mucosal surfaces such as in the gingival crevice and provide a barrier to
the ingress of colonizing microorganisms. However, epithelial cells are more than a passive …

Porphyromonas gingivalis, a major oral pathobiont, evades canonical host pathogen
clearance in human primary gingival epithelial cells (GECs) by initiating a non-canonical …

Endothelin-1 (ET-1), the most potent vasoconstrictor identified to date, contributes to
cerebrovascular dysfunction and brain ET-1 levels were shown to be related to Alzheimer's …