Nociceptor sensory neurons protect organisms from danger by eliciting pain and driving
avoidance. Pain also accompanies many types of inflammation and injury. It is increasingly …

Pain results from the activation of a subset of sensory neurones termed nociceptors and has
evolved as a “detect and protect” mechanism. However, lesion or disease in the sensory …

The past few decades have witnessed a huge leap forward in our understanding of the
mechanistic underpinnings of pain, in normal states where it helps protect from injury, and …

Chronic neuropathic pain is a major morbidity of neural injury, yet its mechanisms are
incompletely understood. Hypersensitivity to previously non-noxious stimuli (allodynia) is a …

The voltage-gated sodium channel NaV1. 9 is preferentially expressed in nociceptors and
has been shown in rodent models to have a major role in inflammatory and neuropathic …

Neuropathic pain arises from injury to the nervous system. Conditions associated with
neuropathic pain are diverse, and lesions and/or pathological changes in the central …

Idiopathic trigeminal neuralgia (TN) is a debilitating pain disorder characterized by episodic
unilateral facial pain along the territory of branches of the trigeminal nerve. Human pain …

In recent years, the disappointing history of translation in pain research has undergone
significant scrutiny. The escalation of knowledge and understanding related to presumed …

Sensory abnormalities generated by nerve injury, peripheral neuropathy or disease are
often expressed as neuropathic pain. This type of pain is frequently resistant to therapeutic …

Knowledge about the mechanisms of transmission and the processing of nociceptive
information, both in healthy and pathological states, has greatly expanded in recent years …