Triple-negative (TNBC) is the most lethal subtype of breast cancer owing to high
heterogeneity, aggressive nature, and lack of treatment options. Chemotherapy remains the …

Cancer is a problem with worldwide importance and is the second leading cause of death
globally. Cancer cells reprogram their metabolism to support their uncontrolled expansion …

Triple-negative breast cancer (TNBC) is not a unique disease, encompassing multiple
entities with marked histopathological, transcriptomic and genomic heterogeneity. Despite …

Platinum-based anticancer drugs, including cisplatin, carboplatin, oxaliplatin, nedaplatin,
and lobaplatin, are heavily applied in chemotherapy regimens. However, the intrinsic or …

Distinct regions harboring cancer stem cells (CSCs) have been identified within the
microenvironment of various tumors, and as in the case of their healthy counterparts, these …

Hypoxia is a condition always present in tumor environment owing to the fast growth of
tumor cells not supported by adequate blood supply. There is increasing evidence that …

Cancer with a complex pathological process is a major disease to human welfare. Due to
the imbalance between oxygen (O2) supply and consumption, hypoxia is a natural …

Rapid progress in molecular cancer biology coupled with the discovery of novel oncology
drugs has opened new horizons for cancer target discovery. As one of the crucial signaling …

Background: Lung adenocarcinoma (LUAD), the major subtype of lung cancer, is among the
leading cause of cancer-related death worldwide. Energy-related metabolic reprogramming …

The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor regulating
adaptive and maladaptive responses toward exogenous and endogenous signals …