Bone is the second most commonly transplanted tissue worldwide, with over four million
operations using bone grafts or bone substitute materials annually to treat bone defects …

Poly (lactic-co-glycolic) acid (PLGA) has attracted considerable interest as a base material
for biomedical applications due to its:(i) biocompatibility;(ii) tailored biodegradation rate …

Bone tissue engineering is a highly interdisciplinary field that seeks to tackle the most
challenging bone-related clinical issues. The major components of bone tissue engineering …

Repair and regeneration of large bone defects is still a challenge, especially for defects
which are the irregular and complex. Three-dimension (3D) printing, as an advanced …

Electrospinning, a technique well known for fabricating nanoscale fibers, has recently been
studied extensively due to its various advantages such as high surface-to-volume ratio …

It has been demonstrated that nanostructured materials, compared with conventional
materials, may promote greater amounts of specific protein interactions, thereby more …

Oxidative stress induced by reactive oxygen species (ROS) overproduction would hinder
bone healing process at the interface of bone/implant, yet underlying mechanism remains to …

Many polymeric materials have been developed and introduced for bone regeneration.
Especially, their nanofibrous forms are mostly applied for artificial extracellular matrices …

Nanosize hydroxyapatite (nHAp) doped with varying levels of Fe3+ (Fe-nHAp of average
size 75 nm) was synthesized by hydrothermal and microwave techniques. The samples …

Electrospun silk fibroin (SF) scaffolds provide large surface area, high porosity, and
interconnection for cell adhesion and proliferation and they may replace collagen for many …