Alzheimer's disease (AD) constitutes the most prominent form of dementia among elderly
individuals worldwide. Disease modeling using murine transgenic mice was first initiated …

Over the past decades, significant efforts have been made to understand the precise
mechanisms underlying the pathogenesis of Alzheimer's disease (AD), the most common …

The majority of Alzheimer's disease (AD) cases are late-onset and occur sporadically,
however most mouse models of the disease harbor pathogenic mutations, rendering them …

The long-lived Chilean rodent (Octodon degus) has been reported to show spontaneous
age-dependent neuropathology and cognitive impairments similar to those observed in …

The most significant genetic risk factor for developing late-onset Alzheimer's disease (AD) is
the ε4 allele of apolipoprotein E (APOE4). APOE genotype and biological sex are key …

Alzheimer's disease (AD) is an incurable neurodegenerative disease affecting over 45
million people worldwide. Transgenic mouse models have made remarkable contributions …

Transgenic models are useful tools for studying the pathogenesis of and drug development
for Alzheimer's Disease (AD). AD models are constructed usually using overexpression or …

Alzheimer's disease (AD) is one of the most common, severe neurodegenerative brain
disorder characterized by the accumulation of amyloid-beta plaques, neurofibrillary tangles …

In the last decade, the role of the microbiota–gut–brain axis has been gaining momentum in
the context of many neurodegenerative and metabolic disorders, including Alzheimer's …

Background: The endosomal retromer complex system is a key controller for trafficking of
proteins. Downregulation of its recognition core proteins, such as VPS35, is present in …