Those working with Alzheimer's and other dementias have been frustrated by the
implacability of these diseases. Regardless of limited symptomatic treatment, 1 there are no …

Nontransgenic and 3xTG transgenic mice, which express mutant transgenes encoding
human amyloid precursor protein (hAPP) along with Alzheimer's disease–associated …

Background: The endosomal retromer complex system is a key controller for trafficking of
proteins. Downregulation of its recognition core proteins, such as VPS35, is present in …

Two distinct types of microscopic diffusion anisotropy (MA) are compared in brain for both
normal control and transgenic (3xTg‐AD) mice, which develop Alzheimer's disease …

One year after the start of the COVID-19 pandemic, its secondary impacts can be globally
observed. Some of them result from physical distancing and severe social contact …

Abstract Alzheimer's disease (AD), the main dementia type accounting for over 70% of the
entire dementia population, progressive decline in memory and executive function. AD …

Abnormal inflammatory response in the central nervous system plays a critical role in
various neurological disorders such as Parkinson's disease, Alzheimer's disease and …

Genetically modified mice are engineered as models for human diseases. These mouse
models include inbred strains, mutants, gene knockouts, gene knockins, and …

A new hypothesis highlights sleep-dependent learning/memory consolidation and regards
the sleep-wake cycle as a modulator of β-amyloid and tau Alzheimer's disease (AD) …

The brain is a complex organ that controls thought, memory, emotion, touch, motor skills,
vision, breathing, temperature, hunger, and many processes that regulate our body …