Is lithium neuroprotective? An updated mechanistic illustrated review

F Ghanaatfar, A Ghanaatfar, P Isapour… - Fundamental & …, 2023 - Wiley Online Library
Neurodegeneration is a pathological process characterized by progressive neuronal
impairment, dysfunction, and loss due to mitochondrial dysfunction, oxidative stress …

The impact of cerebral ischemia on antioxidant enzymes activity and neuronal damage in the Hippocampus

J Sadeghzadeh, L Hosseini, A Mobed… - Cellular and Molecular …, 2023 - Springer
Cerebral ischemia and subsequent reperfusion, leading to reduced blood supply to specific
brain areas, remain significant contributors to neurological damage, disability, and mortality …

Lithium intoxication induced pyroptosis via ROS/NF‐κB/NLRP3 inflammasome regulatory networks in kidney of mice

H Jing, F Wang, X Gao - Environmental toxicology, 2022 - Wiley Online Library
Humans and animals may be exposed to increasing contaminant lithium (Li) concentrations
in the environment with the use and disposal of Li‐containing products. Meanwhile, Li plays …

Synthesis of quercetin-metal complexes, in vitro and in silico anticholinesterase and antioxidant evaluation, and in vivo toxicological and anxiolitic activities

WMB da Silva, S de Oliveira Pinheiro, DR Alves… - Neurotoxicity …, 2020 - Springer
The level of acetylcholine, a neurotransmitter essential for processing memory and learning,
is lower in the brains of patients with Alzheimer's disease due to the higher concentration of …

Mood and behavior regulation: interaction of lithium and dopaminergic system

M Mohamadian, H Fallah, Z Ghofrani-Jahromi… - Naunyn-Schmiedeberg's …, 2023 - Springer
Lithium is one of the most effect mood-stabilizing drugs prescribed especially for bipolar
disorder. Lithium has wide range effects on different molecular factors and neural …

Electric foot-shock induces neurobehavioral aberrations due to imbalance in oxidative status, stress hormone, neurochemical profile, and irregular cortical-beta wave …

R Nisar, Z Batool, S Haider - Life Sciences, 2023 - Elsevier
Neuropsychiatric disorders can be modeled on animals to investigate the neural mechanism
underlying these disorders. Models of neuropsychiatric disorders, such as anxiety, basically …

Oxidized Cell‐Free DNA Role in the Antioxidant Defense Mechanisms under Stress

AD Filev, GV Shmarina, ES Ershova… - Oxidative Medicine …, 2019 - Wiley Online Library
The present study focuses on the investigation of the oxidized cell‐free DNA (cfDNA)
properties in several experimental models, including cultured cerebellum cells, peripheral …

BOTOX® counteracts the innate anxiety-related behaviours in correlation with increased activities of key antioxidant enzymes in the hippocampus of ageing …

A Yesudhas, RK Radhakrishnan, A Sukesh… - Biochemical and …, 2021 - Elsevier
Cholinergic crisis and oxidative stress in the hippocampus of the brain have been known to
induce anxiety disorders upon ageing. BOTOX® is a widely used therapeutic form of …

Interaction of lithium and sleep deprivation on memory performance and anxiety-like behavior in male Wistar rats

Z Torabi, M Rezaie, A Aramvash… - Behavioural Brain …, 2022 - Elsevier
Sleep plays a crucial role in the modulation of physiological and cognitive functions. Many
studies have reported the impairment effect of sleep deprivation (SD) on cognitive functions …

Apoptosis in hippocampal tissue induced by oxidative stress in testosterone deprived male rats

SJ Muthu, P Seppan - The Aging Male, 2020 - Taylor & Francis
The testosterone decline is one of the potential causes of oxidative stress-induced anxiety
and depressive behaviors, and cognitive impairment induces irreversible neuronal damage …