Gregoire, Francine M., Cynthia M. Smas, and Hei Sook Sul. Understanding Adipocyte
Differentiation. Physiol. Rev. 78: 783–809, 1998.—The adipocyte plays a critical role in …

Tumor necrosis factor-α (TNF-α) is an important mediator of insulin resistance in obesity and
diabetes through its ability to decrease the tyrosine kinase activity of the insulin receptor (IR) …

Obesity is highly associated with insulin resistance and is the biggest risk factor for non-
insulin-dependent diabetes mellitus,,. The molecular basis of this common syndrome …

B. DNA binding properties C. PPAR ligand-binding properties D. Alternative pathways for
PPAR activation E. PPAR-mediated transactivation properties III. Physiological Aspects A …

Insulin resistance is a common problem associated with infections and cancer and, most
importantly, is the central component of non-insulin-dependent diabetes mellitus. We have …

Cytokines appear to be major regulators of adipose tissue metabolism. Therapeutic
modulation of cytokine systems offers the possibility of major changes in adipose tissue …

Mice deficient in C/EBPα have defective development of adipose tissue, but the precise role
of C/EBPα has not been defined. Fibroblasts from C/EBPα (−/−) mice undergo adipose …

Liver regeneration stimulated by a loss of liver mass leads to hepatocyte and
nonparenchymal cell proliferation and rapid restoration of liver parenchyma. Mice with …

A previous study reported the increased expression of the cytokine TNF in the adipose
tissue of genetically obese rodents. To examine this paradigm in humans, we studied TNF …

Recent data have suggested a key role for tumor necrosis factor (TNF)-α in the insulin
resistance of obesity and non-insulin-dependent diabetes mellitus (NIDDM). TNF-α …