TNF-α impairs insulin signaling and insulin stimulation of glucose uptake in C2C12muscle cells

LF del Aguila, KP Claffey… - American Journal of …, 1999 - journals.physiology.org
Physiological stressors such as sepsis and tissue damage initiate an acute immune
response and cause transient systemic insulin resistance. This study was conducted to …

Transcriptional control of adipogenesis

SM Rangwala, MA Lazar - Annual review of nutrition, 2000 - annualreviews.org
▪ Abstract The major transcriptional factors involved in the adipogenic process include
proteins belonging to the CCAAT/enhancer binding protein family, peroxisome proliferator …

The linkage between inflammation and Type 2 diabetes mellitus

NG Cruz, LP Sousa, MO Sousa, NT Pietrani… - Diabetes research and …, 2013 - Elsevier
The Type 2 diabetes mellitus (DM2) is considered nowadays as one of the most important
chronic disturbances because of the significant number of people with diabetes and its …

Functional analysis of tumor necrosis factor (TNF) receptors in TNF-α-mediated insulin resistance in genetic obesity

KT Uysal, SM Wiesbrock, GS Hotamisligil - Endocrinology, 1998 - academic.oup.com
Although obesity has become the most common metabolic disorder in the developed world
and is highly associated with insulin resistance and noninsulin-dependent diabetes mellitus …

Maternal and postnatal overnutrition differentially impact appetite regulators and fuel metabolism

H Chen, D Simar, K Lambert, J Mercier… - Endocrinology, 2008 - academic.oup.com
Maternal obesity is increasing, and it is known that the intrauterine experience programs
fetal and newborn metabolism. However, the relative contributions of pre-or postnatal factors …

Advancing age and insulin resistance: role of plasma tumor necrosis factor-α

G Paolisso, MR Rizzo, G Mazziotti… - American Journal …, 1998 - journals.physiology.org
In 70 healthy subjects with a large age range, the relationships between plasma tumor
necrosis factor-α (TNF-α) and body composition, insulin action, and substrate oxidation were …

Effects of tumour necrosis factor alpha (TNFα) on glucose transport and lipid metabolism of newly-differentiated human fat cells in cell culture

H Hauner, TH Petruschke, M Russ, K Röhrig, J Eckel - Diabetologia, 1995 - Springer
Tumour necrosis factor alpha (TNFα) has been found to cause a delipidation of fat cells and
a decrease of the adipose tissue mass. In the present study, we tried to elucidate some of …

The systemic-level repercussions of cancer-associated inflammation mediators produced in the tumor microenvironment

D Aguilar-Cazares, R Chavez-Dominguez… - Frontiers in …, 2022 - frontiersin.org
The tumor microenvironment is a dynamic, complex, and redundant network of interactions
between tumor, immune, and stromal cells. In this intricate environment, cells communicate …

TNF-α induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c)

M Endo, T Masaki, M Seike… - … biology and medicine, 2007 - journals.sagepub.com
We investigated the effect of tumor necrosis factor-α (TNF-α), a member of the
proinflammatory cytokine family, on steatosis of the mouse liver by analyzing morphological …

Elevated serum levels of tumor necrosis factor alpha in normal-weight women with polycystic ovary syndrome

F Gonzalez, K Thusu, E Abdel-Rahman, A Prabhala… - Metabolism, 1999 - Elsevier
Since an increase in tumor necrosis factor alpha (TNFα) expression has been associated
with insulin resistance, this study was undertaken to determine the status of circulating TNFα …