The fundamental role played by neutrophils for an efficient, acute inflammatory response
has long been appreciated, with the underlying molecular and cellular mechanisms largely …

Abstract Treatment of inflammatory diseases today is largely based on interrupting the
synthesis or action of mediators that drive the host's response to injury. Non-steroidal anti …

Neutrophil extracellular traps (NETs), the product of NETosis, is found to localize pathogens
and crystals in immune response. Recent studies have found that excessive NETs lead to …

The popular view that all lipid mediators are pro-inflammatory arises largely from the finding
that nonsteroidal anti-inflammatory drugs block the biosynthesis of prostaglandins. The …

Abbreviations: Apaf, apoptosis protease activation factor; CAD, caspase-activated DNAse;
caspase, cysteine aspartate-directed protease; CAPK, ceramide-activated protein kinase; …

Inflammation has evolved as a protective response to insult or injury, it's a primordial
response that eliminates or neutralises foreign organisms or material, the resolution of …

The presence of two dedicated phagocytic cells working cooperatively represents an
advantageous innate immune strategy that allows the efficient and safe utilization of …

The innate immune system is the first line of host defense against invading microorganisms.
Polymorphonuclear leukocytes (PMNs or neutrophils) are the most abundant leukocyte in …

Human neutrophils constitutively undergo apoptosis and this process is critical for the
resolution of inflammation. Whilst neutrophil apoptosis can be modulated by a wide variety …

Macrolides are widely used as antibacterial drugs. Clinical and experimental data, however,
indicate that they also modulate inflammatory responses, both contributing to the treatment …