Red blood cells (RBCs) have historically been considered passive bystanders in
thrombosis. However, clinical and epidemiological studies have associated quantitative and …

Human red blood cells (RBC) are highly differentiated cells that have lost all organelles and
most intracellular machineries during their maturation process. RBC are fundamental for the …

In contrast to an obsolete notion that erythrocytes, or red blood cells (RBC s), play a passive
and minor role in haemostasis and thrombosis, over the past decades there has been …

Clinical observations and accumulating laboratory evidence support a complex interplay
between coagulation, inflammation, innate immunity and fibrinolysis in venous …

Venous thrombi, fibrin-and rbc-rich clots triggered by inflammation and blood stasis, underlie
devastating, and sometimes fatal, occlusive events. During intravascular fibrin deposition …

Mid-life stage adults are at higher risk of developing venous thrombosis
(VT)/thromboembolism (VT/E). Aging is characterized by an overproduction of reactive …

Sickle cell anaemia (SCA) is the consequence of abnormal haemoglobin production due to
an inherited point mutation in the β‐globin gene. The resulting haemoglobin tetramer is …

Suicidal death of erythrocytes, or eryptosis, is characterized by cell shrinkage and cell
membrane scrambling leading to phosphatidylserine exposure at the cell surface. Eryptosis …

Deep vein thrombosis and pulmonary embolism, collectively termed venous
thromboembolism (VTE), affect over 1 million Americans each year. VTE is triggered by …

Platelets are understood to assist host innate immune responses against infection, although
direct evidence of this function in any human disease, including malaria, is unknown. Here …