[HTML][HTML] Polycystic ovary syndrome and oxidative stress—from bench to bedside

N Zeber-Lubecka, M Ciebiera, EE Hennig - International journal of …, 2023 - mdpi.com
Oxidative stress (OS) is a condition that occurs as a result of an imbalance between the
production of reactive oxygen species (ROS) and the body's ability to detoxify and neutralize …

[PDF][PDF] Ovarian microenvironment: Challenges and opportunities in protecting against chemotherapy-associated ovarian damage

Y Guo, L Xue, W Tang, J Xiong, D Chen… - Human …, 2024 - academic.oup.com
BACKGROUND Chemotherapy-associated ovarian damage (CAOD) is one of the most
feared short-and long-term side effects of anticancer treatment in premenopausal women …

Follicular hyperstimulation dysgenesis: new explanation for adverse effects of excessive FSH in ovarian stimulation

ZL Clark, ML Ruebel, PZ Schall, KR Karl… - …, 2022 - academic.oup.com
High follicle-stimulating hormone (FSH) doses during ovarian stimulation protocols for
assisted reproductive technologies (ART) are detrimental to ovulatory follicle function and …

[HTML][HTML] Chronic low-grade inflammation and ovarian dysfunction in women with polycystic ovarian syndrome, endometriosis, and aging

M Orisaka, T Mizutani, Y Miyazaki, A Shirafuji… - Frontiers in …, 2023 - frontiersin.org
The ovarian microenvironment is critical for follicular development and oocyte maturation.
Maternal conditions, including polycystic ovary syndrome (PCOS), endometriosis, and …

Decreased expression of EZH2 in granulosa cells contributes to endometriosis-associated infertility by targeting IL-1R2

X Lin, X Tong, Y Zhang, W Gu, Q Huang… - …, 2023 - academic.oup.com
The mechanism by which endometriosis, a common gynecological disease characterized by
chronic pelvic pain and infertility, causes infertility remains elusive. Luteinized unruptured …

[HTML][HTML] Berberine protects cyclophosphamide and busulfan-induced premature ovarian insufficiency in mouse model

Y Peng, L Sun, W Guo, Z Liu, T Wang, T Zou… - Journal of …, 2023 - Elsevier
Premature ovarian insufficiency (POI) is a clinical syndrome that declines ovarian function in
women. Berberine (BBR) is a compound with anti-inflammatory, antioxidant, and anti …

Inflammasomes in human reproductive diseases

Y Chen, C Miao, Y Zhao, L Yang… - Molecular Human …, 2023 - academic.oup.com
Inflammasomes are multi-protein complexes localized within immune and non-immune cells
that induce caspase activation, proinflammatory cytokine secretion, and ultimately pyroptosis …

[HTML][HTML] Impact of cigarette smoking on the expression of oxidative stress-related genes in cumulus cells retrieved from healthy women undergoing IVF

F Konstantinidou, MC Budani, A Sarra… - International Journal of …, 2021 - mdpi.com
The female reproductive system represents a sensitive target of the harmful effects of
cigarette smoke, with folliculogenesis as one of the ovarian processes most affected by this …

[HTML][HTML] Pueratin improves diminished ovarian reserve by inhibiting apoptosis

Q Qi, X Zhang, L Yao, Y Chen… - Experimental and …, 2021 - spandidos-publications.com
Pueratin (Pue) is an extract from Pueraria lobata, and exhibits therapeutic effects for the
treatment of inflammation. However, the beneficial effects and mechanisms underlying Pue …

[HTML][HTML] The amelioration of ovarian dysfunction by hesperidin in malathion-treated mice through the overexpression of PCNA and FSHR proteins

M Zarein, A Zarban, H Shoorei, M Gharekhani… - Heliyon, 2023 - cell.com
Objective Malathion (MAL), a pesticide used for decades, is a highly toxic substance.
Several studies have documented the negative effects of such agents on reproductive organ …