Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

HS Kwon, SH Koh - Translational neurodegeneration, 2020 - Springer
Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer's
disease, Parkinson's disease, and amyotrophic lateral sclerosis. Microglia and astrocytes …

Ageing as a risk factor for neurodegenerative disease

Y Hou, X Dan, M Babbar, Y Wei… - Nature Reviews …, 2019 - nature.com
Ageing is the primary risk factor for most neurodegenerative diseases, including Alzheimer
disease (AD) and Parkinson disease (PD). One in ten individuals aged≥ 65 years has AD …

Microglia in neurodegeneration

S Hickman, S Izzy, P Sen, L Morsett, J El Khoury - Nature neuroscience, 2018 - nature.com
The neuroimmune system is involved in development, normal functioning, aging, and injury
of the central nervous system. Microglia, first described a century ago, are the main …

[HTML][HTML] Role of neuroinflammation in neurodegenerative diseases

WW Chen, XIA Zhang… - Molecular medicine …, 2016 - spandidos-publications.com
Neurodegeneration is a phenomenon that occurs in the central nervous system through the
hallmarks associating the loss of neuronal structure and function. Neurodegeneration is …

Non-neuronal cells in amyotrophic lateral sclerosis—from pathogenesis to biomarkers

BF Vahsen, E Gray, AG Thompson, O Ansorge… - Nature Reviews …, 2021 - nature.com
The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS)
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …

Inflammation in ALS/FTD pathogenesis

ME McCauley, RH Baloh - Acta neuropathologica, 2019 - Springer
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are
neurodegenerative diseases that overlap in their clinical presentation, pathology and …

Unhealthy gut, unhealthy brain: The role of the intestinal microbiota in neurodegenerative diseases

LJ Spielman, DL Gibson, A Klegeris - Neurochemistry international, 2018 - Elsevier
The number of bacterial cells living within the human body is approximately equal to, or
greater than, the total number of human cells. This dynamic population of microorganisms …

[HTML][HTML] Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders

MT Kabir, MH Rahman, M Shah, MR Jamiruddin… - Biomedicine & …, 2022 - Elsevier
Abstract Neurodegenerative disorders (NDs) including Alzheimer's disease, Parkinson's
disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis have …

Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets

C Gao, J Jiang, Y Tan, S Chen - Signal transduction and targeted …, 2023 - nature.com
Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

Apoptosis and oxidative stress in neurodegenerative diseases

E Radi, P Formichi, C Battisti… - Journal of Alzheimer's …, 2014 - content.iospress.com
Neurodegenerative disorders affect almost 30 million individuals leading to disability and
death. These disorders are characterized by pathological changes in disease-specific areas …