Detailed characterization of human pancreatic islets is key to elucidating the
pathophysiology of all forms of diabetes, especially type 2 diabetes. However, access to …

Abstract Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of
insulin producing pancreatic β-cells. One of the genes associated with T1D is TYK2, which …

One of the hallmarks of type 1 but also type 2 diabetes is pancreatic islet inflammation,
associated with altered pancreatic islet function and structure, if unresolved. IL-1β is a …

The IL-22RA1 receptor is highly expressed in the pancreas, and exogenous IL-22 has been
shown to reduce endoplasmic reticulum and oxidative stress in human pancreatic islets and …

Abstract Aquaglyceroporin 7 (AQP7) facilitates glycerol flux across the plasma membrane
with a critical physiological role linked to metabolism, obesity, and associated diseases …

Abstract Aims/hypothesis The Latino population has been systematically underrepresented
in large-scale genetic analyses, and previous studies have relied on the imputation of …

Pancreatic β cells play an essential role in the control of systemic glucose homeostasis as
they sense blood glucose levels and respond by secreting insulin. Upon stimulating glucose …

Abstract Objective Ependymin-Related Protein 1 (EPDR1) was recently identified as a
secreted human batokine regulating mitochondrial respiration linked to thermogenesis in …

Aims Reduced expression of exocytotic genes is associated with functional defects in insulin
exocytosis contributing to impaired insulin secretion and type 2 diabetes (T2D) …

Aim SYT11 and SYT13, two calcium‐insensitive synaptotagmins, are downregulated in
islets from type 2 diabetic donors, but their function in insulin secretion is unknown. To …