Mechanisms of action of currently used antiseizure drugs
GJ Sills, MA Rogawski - Neuropharmacology, 2020 - Elsevier
Antiseizure drugs (ASDs) prevent the occurrence of seizures; there is no evidence that they
have disease-modifying properties. In the more than 160 years that orally administered …
have disease-modifying properties. In the more than 160 years that orally administered …
Neonicotinoid insecticides: molecular targets, resistance, and toxicity
K Matsuda, M Ihara, DB Sattelle - Annual review of …, 2020 - annualreviews.org
Neonicotinoids have been used to protect crops and animals from insect pests since the
1990s, but there are concerns regarding their adverse effects on nontarget organisms …
1990s, but there are concerns regarding their adverse effects on nontarget organisms …
Shared structural mechanisms of general anaesthetics and benzodiazepines
Most general anaesthetics and classical benzodiazepine drugs act through positive
modulation of γ-aminobutyric acid type A (GABAA) receptors to dampen neuronal activity in …
modulation of γ-aminobutyric acid type A (GABAA) receptors to dampen neuronal activity in …
GABAA receptor signalling mechanisms revealed by structural pharmacology
S Masiulis, R Desai, T Uchański, I Serna Martin… - Nature, 2019 - nature.com
Type-A γ-aminobutyric (GABAA) receptors are ligand-gated chloride channels with a very
rich pharmacology. Some of their modulators, including benzodiazepines and general …
rich pharmacology. Some of their modulators, including benzodiazepines and general …
[PDF][PDF] Lactate buildup at the site of chronic inflammation promotes disease by inducing CD4+ T cell metabolic rewiring
Accumulation of lactate in the tissue microenvironment is a feature of both inflammatory
disease and cancer. Here, we assess the response of immune cells to lactate in the context …
disease and cancer. Here, we assess the response of immune cells to lactate in the context …
Structural and dynamic mechanisms of GABAA receptor modulators with opposing activities
Abstract γ-Aminobutyric acid type A (GABAA) receptors are pentameric ligand-gated ion
channels abundant in the central nervous system and are prolific drug targets for treating …
channels abundant in the central nervous system and are prolific drug targets for treating …
Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling
Microglia dynamically survey the brain parenchyma. Microglial processes interact with
neuronal elements; however, what role neuronal network activity plays in regulating …
neuronal elements; however, what role neuronal network activity plays in regulating …
GABAkines–Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors
Positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors or GABAkines
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …
GABAA receptors: structure, function, pharmacology, and related disorders
Background γ-Aminobutyric acid sub-type A receptors (GABAARs) are the most prominent
inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion …
inhibitory neurotransmitter receptors in the CNS. They are a family of ligand-gated ion …
Molecular mechanisms of metabotropic GABAB receptor function
Metabotropic γ-aminobutyric acid G protein–coupled receptors (GABAB) represent one of
the two main types of inhibitory neurotransmitter receptors in the brain. These receptors act …
the two main types of inhibitory neurotransmitter receptors in the brain. These receptors act …