Background The ventral tegmental area (VTA) is a dopaminergic brain area that is critical in
the development and maintenance of addiction. During withdrawal from chronic ethanol …

Elevated levels of cholesterol in the blood can induce endothelial dysfunction, a condition
characterized by impaired nitric oxide production and decreased vasodilatory capacity …

The periaqueductal gray (PAG) is a complex mesencephalic structure involved in the
integration and execution of active and passive self-protective behaviors against imminent …

Cannabinoids exert therapeutic effects on several diseases such as chronic pain and startle
disease by targeting glycine receptors (GlyRs). Our previous studies have shown that …

Autism spectrum disorder is a neurodevelopmental syndrome diagnosed primarily by
persistent deficits in social interactions and communication, unusual sensory reactivity …

In recent years, indolylglyoxylamide-based derivatives have received much attention due to
their application in drug design and discovery, leading to the development of a wide array of …

Treating the signs and symptoms of anxiety is an everyday challenge in clinical practice.
When choosing between treatment options, anxiety needs to be understood in the …

Immune cells express γ-aminobutyric acid receptors (GABA-R), and GABA administration
can inhibit effector T cell responses in models of autoimmune disease. The pharmacokinetic …

Mutations of GABAAR have reportedly led to epileptic encephalopathy and
neurodevelopmental disorders. We have identified a novel de novo T292S missense variant …

Background Alcohol use disorder (AUD) is a chronic relapsing brain disorder. GABAA
receptor (GABAAR) subunits are a target for the pharmacological effects of alcohol …