Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research
X Tong, R Tang, M Xiao, J Xu, W Wang… - Journal of hematology & …, 2022 - Springer
Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …
body against pathogenic substances. This process, called regulated cell death (RCD), is …
Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy
W Gao, X Wang, Y Zhou, X Wang, Y Yu - Signal transduction and …, 2022 - nature.com
In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led
to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors …
to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors …
Copper induces cell death by targeting lipoylated TCA cycle proteins
Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations
exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How …
exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How …
Apoptotic cell death in disease—Current understanding of the NCCD 2023
I Vitale, F Pietrocola, E Guilbaud… - Cell Death & …, 2023 - nature.com
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …
The role of BCL-2 family proteins in regulating apoptosis and cancer therapy
S Qian, Z Wei, W Yang, J Huang, Y Yang… - Frontiers in …, 2022 - frontiersin.org
Apoptosis, as a very important biological process, is a response to developmental cues or
cellular stress. Impaired apoptosis plays a central role in the development of cancer and …
cellular stress. Impaired apoptosis plays a central role in the development of cancer and …
PI3K/Akt/mTOR pathway and its role in cancer therapeutics: are we making headway?
Y Peng, Y Wang, C Zhou, W Mei, C Zeng - Frontiers in oncology, 2022 - frontiersin.org
Cancer is a severe public health issue that is a leading cause of mortality globally. It is also
an impediment to improving life expectancy worldwide. Furthermore, the global burden of …
an impediment to improving life expectancy worldwide. Furthermore, the global burden of …
Regulated cell death (RCD) in cancer: key pathways and targeted therapies
F Peng, M Liao, R Qin, S Zhu, C Peng, L Fu… - Signal transduction and …, 2022 - nature.com
Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …
form of cell death that can be regulated by a variety of biomacromolecules, which is …
Necroptosis, pyroptosis and apoptosis: an intricate game of cell death
Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …
from embryonic development, organ maintenance, and aging to the coordination of immune …
Broadening horizons: the role of ferroptosis in cancer
The discovery of regulated cell death processes has enabled advances in cancer treatment.
In the past decade, ferroptosis, an iron-dependent form of regulated cell death driven by …
In the past decade, ferroptosis, an iron-dependent form of regulated cell death driven by …
Unlocking the potential of antibody–drug conjugates for cancer therapy
Nine different antibody–drug conjugates (ADCs) are currently approved as cancer
treatments, with dozens more in preclinical and clinical development. The primary goal of …
treatments, with dozens more in preclinical and clinical development. The primary goal of …