In eukaryotes, poly (A) tails are present on almost every mRNA. Early experiments led to the
hypothesis that poly (A) tails and the cytoplasmic polyadenylate-binding protein (PABPC) …

Autoimmunity and autoinflammation arise from aberrant immunological and inflammatory
responses toward self-components, contributing to various autoimmune diseases and …

Abstract Interleukin-6 (IL-6) is a cytokine, which is involved in innate and acquired immunity,
in neural cell maintenance and in metabolism. IL-6 can be synthesized by many different …

Post-transcriptional regulation is involved in the regulation of many inflammatory genes. Zinc
finger protein 36 (ZFP36) family proteins are RNA-binding proteins involved in messenger …

Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune
system and are the first line of host defense against microbial pathogens by recognizing …

Robust expansion of adoptively transferred T cells is a prerequisite for effective cancer
immunotherapy, but how many genes in the genome modulate T cell expansion remains …

Genetic information that is transcribed from DNA to mRNA, and then translated from mRNA
to protein, is regulated by complex and sophisticated post-transcriptional mechanisms …

Inflammation, a hallmark of cancer, has been associated with tumor progression, transition
into malignant phenotype and efficacy of the chemotherapeutic agents in cancer. Chronic …

Autoimmune diseases (ADs) are chronic pathologies generated by the loss of immune
tolerance to the body's own cells and tissues. There is growing recognition that RNA …

Regulation of mRNA degradation is critical for a diverse array of cellular processes and
developmental cell fate decisions. Many methods for determining mRNA half-lives rely on …