Inflammation and immune dysfunction in Parkinson disease

MG Tansey, RL Wallings, MC Houser… - Nature Reviews …, 2022 - nature.com
Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral
organs as well as the central nervous system and involves a fundamental role of …

The microbiome–gut–brain axis in Parkinson disease—from basic research to the clinic

AH Tan, SY Lim, AE Lang - Nature Reviews Neurology, 2022 - nature.com
Evidence for a close bidirectional link between the brain and the gut has led to a paradigm
shift in neurology, especially in the case of Parkinson disease (PD), in which gastrointestinal …

The gut microbiota–brain axis in behaviour and brain disorders

LH Morais, HL Schreiber IV… - Nature Reviews …, 2021 - nature.com
In a striking display of trans-kingdom symbiosis, gut bacteria cooperate with their animal
hosts to regulate the development and function of the immune, metabolic and nervous …

Inflammation in Parkinson's disease: mechanisms and therapeutic implications

M Pajares, A I. Rojo, G Manda, L Boscá, A Cuadrado - Cells, 2020 - mdpi.com
Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized
by the death of dopaminergic neurons that project from the substantia nigra pars compacta …

Neurodegeneration and inflammation—an interesting interplay in Parkinson's disease

C Marogianni, M Sokratous, E Dardiotis… - International journal of …, 2020 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disorder, caused by, so far, unknown
pathogenetic mechanisms. There is no doubt that pro-inflammatory immune-mediated …

Periphery and brain, innate and adaptive immunity in Parkinson's disease

AS Harms, SA Ferreira, M Romero-Ramos - Acta neuropathologica, 2021 - Springer
Parkinson's disease (PD) is a neurodegenerative disorder where alpha-synuclein plays a
central role in the death and dysfunction of neurons, both, in central, as well as in the …

Biomarker of neuroinflammation in Parkinson's disease

TW Liu, CM Chen, KH Chang - International journal of molecular sciences, 2022 - mdpi.com
Parkinson's disease (PD) is caused by abnormal accumulation of α-synuclein in
dopaminergic neurons of the substantia nigra, which subsequently causes motor symptoms …

Parkinson disease and the immune system—associations, mechanisms and therapeutics

EK Tan, YX Chao, A West, LL Chan, W Poewe… - Nature Reviews …, 2020 - nature.com
Multiple lines of evidence indicate that immune system dysfunction has a role in Parkinson
disease (PD); this evidence includes clinical and genetic associations between autoimmune …

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

TR Sampson, C Challis, N Jain, A Moiseyenko… - elife, 2020 - elifesciences.org
Amyloids are a class of protein with unique self-aggregation properties, and their aberrant
accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases …

The progress of gut microbiome research related to brain disorders

S Zhu, Y Jiang, K Xu, M Cui, W Ye, G Zhao… - Journal of …, 2020 - Springer
There is increasing evidence showing that the dynamic changes in the gut microbiota can
alter brain physiology and behavior. Cognition was originally thought to be regulated only by …