Inflammation and immune dysfunction in Parkinson disease
Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral
organs as well as the central nervous system and involves a fundamental role of …
organs as well as the central nervous system and involves a fundamental role of …
The microbiome–gut–brain axis in Parkinson disease—from basic research to the clinic
Evidence for a close bidirectional link between the brain and the gut has led to a paradigm
shift in neurology, especially in the case of Parkinson disease (PD), in which gastrointestinal …
shift in neurology, especially in the case of Parkinson disease (PD), in which gastrointestinal …
The gut microbiota–brain axis in behaviour and brain disorders
LH Morais, HL Schreiber IV… - Nature Reviews …, 2021 - nature.com
In a striking display of trans-kingdom symbiosis, gut bacteria cooperate with their animal
hosts to regulate the development and function of the immune, metabolic and nervous …
hosts to regulate the development and function of the immune, metabolic and nervous …
Inflammation in Parkinson's disease: mechanisms and therapeutic implications
M Pajares, A I. Rojo, G Manda, L Boscá, A Cuadrado - Cells, 2020 - mdpi.com
Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized
by the death of dopaminergic neurons that project from the substantia nigra pars compacta …
by the death of dopaminergic neurons that project from the substantia nigra pars compacta …
Neurodegeneration and inflammation—an interesting interplay in Parkinson's disease
C Marogianni, M Sokratous, E Dardiotis… - International journal of …, 2020 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disorder, caused by, so far, unknown
pathogenetic mechanisms. There is no doubt that pro-inflammatory immune-mediated …
pathogenetic mechanisms. There is no doubt that pro-inflammatory immune-mediated …
Periphery and brain, innate and adaptive immunity in Parkinson's disease
Parkinson's disease (PD) is a neurodegenerative disorder where alpha-synuclein plays a
central role in the death and dysfunction of neurons, both, in central, as well as in the …
central role in the death and dysfunction of neurons, both, in central, as well as in the …
Biomarker of neuroinflammation in Parkinson's disease
TW Liu, CM Chen, KH Chang - International journal of molecular sciences, 2022 - mdpi.com
Parkinson's disease (PD) is caused by abnormal accumulation of α-synuclein in
dopaminergic neurons of the substantia nigra, which subsequently causes motor symptoms …
dopaminergic neurons of the substantia nigra, which subsequently causes motor symptoms …
Parkinson disease and the immune system—associations, mechanisms and therapeutics
Multiple lines of evidence indicate that immune system dysfunction has a role in Parkinson
disease (PD); this evidence includes clinical and genetic associations between autoimmune …
disease (PD); this evidence includes clinical and genetic associations between autoimmune …
A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice
Amyloids are a class of protein with unique self-aggregation properties, and their aberrant
accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases …
accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases …
The progress of gut microbiome research related to brain disorders
There is increasing evidence showing that the dynamic changes in the gut microbiota can
alter brain physiology and behavior. Cognition was originally thought to be regulated only by …
alter brain physiology and behavior. Cognition was originally thought to be regulated only by …