Defining the molecular features of radiation-induced glioma: a systematic review and meta-analysis

JP Whitehouse, M Howlett, A Federico… - Neuro-Oncology …, 2021 - academic.oup.com
Background Cranial radiation therapy is essential in treating many pediatric cancers,
especially brain tumors; however, its use comes with the risk of developing second …

[HTML][HTML] Assessment of cannabidiol and Δ9-tetrahydrocannabiol in mouse models of medulloblastoma and ependymoma

C Andradas, J Byrne, M Kuchibhotla, M Ancliffe… - Cancers, 2021 - mdpi.com
Simple Summary Phytocannabinoids Δ9-tetrahydrocannabinol (THC) and cannabidiol
(CBD) have been demonstrated to exhibit anti-cancer activity in preclinical models of brain …

[HTML][HTML] In vivo loss of tumorigenicity in a patient-derived orthotopic xenograft mouse model of ependymoma

JP Whitehouse, H Hii, C Mayoh, M Wong… - Frontiers in …, 2023 - frontiersin.org
Introduction Ependymomas (EPN) are the third most common malignant brain cancer in
children. Treatment strategies for pediatric EPN have remained unchanged over recent …

[PDF][PDF] Glioblastoma organoid technology: an emerging preclinical models for drug discovery

DCR Batara, S Zhou, MC Choi, SH Kim - development, 2022 - j-organoid.org
Glioblastoma multiforme (GBM) is the most prevalent type of primary brain tumor among
adults, and it has a median overall survival of 12 to 15 months upon diagnosis. Despite …

Patient-Derived Orthotopic Xenograft Models for High-Grade Pediatric Brain Cancers

J Buck, H Hii, R Endersby - Patient-Derived Xenografts: Methods and …, 2024 - Springer
Patient-derived orthotopic xenograft (PDOX) mouse models are considered the gold
standard for evidence-based preclinical research in pediatric neuro-oncology. This protocol …

Assessment of Cannabidiol and? 9-Tetrahydrocannabiol in Mouse Models of Medulloblastoma and Ependymoma

C Andradas, J Byrne, M Kuchibhotla… - …, 2021 - nottingham-repository.worktribe.com
Children with medulloblastoma and ependymoma are treated with a multidisciplinary
approach that incorporates surgery, radiotherapy, and chemotherapy; however, overall …

Rare Childhood Malignancy

EM Algar - Cancers, 2021 - search.proquest.com
propose triaging rhabdomyosarcoma for intervention with rapamycin based on tumor
mTORC1/mTORC2 expression profile as a result of their findings showing a relationship …

[PDF][PDF] Neuro-Oncology Advances

JP Whitehouse, AF Meegan Howlett, M Kool… - 2021 - pdfs.semanticscholar.org
Background. Cranial radiation therapy is essential in treating many pediatric cancers,
especially brain tumors; however, its use comes with the risk of developing second …