The oral administration of therapeutic peptides and proteins is favoured from a patient and
commercial point of view. In order to reach the systemic circulation after oral administration …

Approximately one third of newly discovered drug molecules show insufficient water
solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems …

As a result of its ability to target certain drugs and/or peptides to the colonic region for the
treatment of several diseases while avoiding systemic absorption and potential side effects …

Highlights•The market for peptide drugs is constantly growing.•Oral peptide drugs in clinical
trials target severe indications.•Nanoparticles and micelles improve oral bioavailability of …

Since the development of self-emulsifying drug delivery systems (SEDDS) in 1980's, they
attract the attention of researchers in order to confront the challenge of poor water-solubility …

There are many areas in medicine and industry where it would be advantageous to orally
deliver bioactive proteins and peptides (BPPs), including ACE inhibitors, antimicrobials …

Aim The aim of this study was the formation and characterization of various ion pairs of
therapeutic peptides with different surfactants in order to reach a high payload in self …

Background The aim of the study was to develop an oral self-emulsifying drug delivery
system (SEDDS) for exenatide and to evaluate its in vivo efficacy. Methods Exenatide was …

Achieving high oral bioavailability for drugs is a key design objective in drug development. It
is not surprising then that with the growing expectation of peptides as future drugs, there has …

Self-emulsifying drug delivery systems (SEDDS) are considered as a potential platform for
mucosal drug delivery. The in vitro–in vivo correlation, however, is in particular for this type …