[HTML][HTML] Targeting PI3K/AKT signaling pathway in obesity
MS Savova, LV Mihaylova, D Tews, M Wabitsch… - Biomedicine & …, 2023 - Elsevier
Obesity is a disorder with an increasing prevalence, which impairs the life quality of patients
and intensifies societal health care costs. The development of safe and innovative …
and intensifies societal health care costs. The development of safe and innovative …
Production of high molecular-ordered stilbene oligomers for the study of their biological activity: total synthesis, bio-catalyzed synthesis and production by plant …
Though the iconic stilbene resveratrol and its related dimers constitute a top storyline in the
field of natural product research, resveratrol oligomers (condensation> 2) have been left …
field of natural product research, resveratrol oligomers (condensation> 2) have been left …
DU8ML: Machine learning-augmented density functional theory nuclear magnetic resonance computations for high-throughput in silico solution structure validation …
IM Novitskiy, AG Kutateladze - The Journal of Organic Chemistry, 2022 - ACS Publications
Machine learning (ML) profoundly improves the accuracy of the fast DU8+ hybrid density
functional theory/parametric computations of nuclear magnetic resonance spectra, allowing …
functional theory/parametric computations of nuclear magnetic resonance spectra, allowing …
The diterpenoid alkaloids
XY Liu, BW Ke, Y Qin, FP Wang - The alkaloids: chemistry and biology, 2022 - Elsevier
The diterpenoid alkaloids are a family of extremely important natural products that have long
been a research hotspot due to their myriad of intricate structures and diverse biological …
been a research hotspot due to their myriad of intricate structures and diverse biological …
Norditerpenoid alkaloids from Aconitum and Delphinium: Structural relevance in medicine, toxicology, and metabolism
AMA Qasem, Z Zeng, MG Rowan… - Natural Product …, 2022 - pubs.rsc.org
Covering: 77 AD up to 2020 Norditerpenoid alkaloids (NDA), typically N-ethylpiperidine
containing C19 or C18 natural product diterpenes, are hexacycles with several contiguous …
containing C19 or C18 natural product diterpenes, are hexacycles with several contiguous …
Total Synthesis of Puberuline C
T Shimakawa, S Nakamura, H Asai… - Journal of the …, 2022 - ACS Publications
Puberuline C (1) is an architecturally complex C19-diterpenoid alkaloid with a unique ring
fusion pattern. The 6/7/5/6/6/6-membered rings (ABCDEF-rings) contain one tertiary amine …
fusion pattern. The 6/7/5/6/6/6-membered rings (ABCDEF-rings) contain one tertiary amine …
Iridium Acylnitrenoid-Initiated Biomimetic Cascade Cyclizations: Stereodefined Access to Polycyclic δ-Lactams
E Tufano, E Lee, M Barilli, E Casali… - Journal of the …, 2023 - ACS Publications
Ring-fused azacyclic compounds are important building units in the synthesis of biorelevant
natural products, pharmaceutical agents, and molecular materials. Herein, we present a new …
natural products, pharmaceutical agents, and molecular materials. Herein, we present a new …
Divergent Total Syntheses of Napelline-Type C20-Diterpenoid Alkaloids:(−)-Napelline,(+)-Dehydronapelline,(−)-Songorine,(−)-Songoramine,(−)-Acoapetaldine D, and …
S Jin, X Zhao, D Ma - Journal of the American Chemical Society, 2022 - ACS Publications
The napelline-type alkaloids possess an azabicyclo [3.2. 1] octane moiety and an ent-
kaurane-type tetracyclic skeleton (6/6/6/5) along with varied oxidation patterns embedded in …
kaurane-type tetracyclic skeleton (6/6/6/5) along with varied oxidation patterns embedded in …
Myxadazoles, Myxobacterium‐Derived Isoxazole–Benzimidazole Hybrids with Cardiovascular Activities
Y Li, L Zhuo, X Li, Y Zhu, S Wu, T Shen… - Angewandte …, 2021 - Wiley Online Library
There is a continuous need for novel microbial natural products to fill the drying‐up drug
development pipeline. Herein, we report myxadazoles from Myxococcus sp. SDU36, a family …
development pipeline. Herein, we report myxadazoles from Myxococcus sp. SDU36, a family …
[HTML][HTML] Diversity of chemical structures and biosynthesis of polyphenols in nut-bearing species
C Aneklaphakij, T Saigo, M Watanabe… - Frontiers in Plant …, 2021 - frontiersin.org
Nuts, such as peanut, almond, and chestnut, are valuable food crops for humans being
important sources of fatty acids, vitamins, minerals, and polyphenols. Polyphenols, such as …
important sources of fatty acids, vitamins, minerals, and polyphenols. Polyphenols, such as …