High-content screening of diterpenoids from Isodon species as autophagy modulators and the functional study of their antiviral activities
L Huang, Q Fu, JM Dai, BC Yan, D Wang… - Cell Biology and …, 2021 - Springer
Autophagy is a conserved lysosomal degradation process, and abnormal autophagy has
been associated with various pathological processes, eg, neurodegeneration, cancer, and …
been associated with various pathological processes, eg, neurodegeneration, cancer, and …
Synthesis, structural characterization and antiproliferative evaluation of phenylalkylamino‐containing alepterolic acid derivatives
B Wu, XY Wei, N Wang, C Xia, R Bao, J Cao… - Journal of Molecular …, 2023 - Elsevier
Aleuritopteris argentea (SG Gmél.) Fée is a medicinal fern, the main metabolite of which is
an ent-labdane diterpene, ie, alepterolic acid. Previous studies showed that this compound …
an ent-labdane diterpene, ie, alepterolic acid. Previous studies showed that this compound …
ent-Atisane diterpenoids: isolation, structure and bioactivity
GJ Drummond, PS Grant, MA Brimble - Natural Product Reports, 2021 - pubs.rsc.org
Covering: up to 2020 ent-Atisane diterpenoids are a class of over 150 members with diverse
structures and valuable bioactivities. These compounds share a curious history in which the …
structures and valuable bioactivities. These compounds share a curious history in which the …
Flavonoids from tribe Delphineae (Ranunculaceae): phytochemical review and chemotaxonomic value
T Yin, Y Yan, X Yang, W Li - Biochemical Systematics and Ecology, 2021 - Elsevier
This review summarizes the flavonoids isolated from three genera, namely, Aconitum,
Delphinium, and Consolida, belonging to tribe Delphineae in the Ranunculaceae family for …
Delphinium, and Consolida, belonging to tribe Delphineae in the Ranunculaceae family for …
Asymmetric Total Synthesis of Hetidine-Type C20-Diterpenoid Alkaloids: (+)-Talassimidine and (+)-Talassamine
Q Zhang, Z Yang, Q Wang, S Liu, T Zhou… - Journal of the …, 2021 - ACS Publications
Here, we report the first asymmetric total synthesis of (+)-talassimidine and (+)-talassamine,
two hetidine-type C20-diterpenoid alkaloids. A highly regio-and diastereoselective 1, 3 …
two hetidine-type C20-diterpenoid alkaloids. A highly regio-and diastereoselective 1, 3 …
Integrating Metabolomics and Transcriptomics to Unveil Atisine Biosynthesis in Aconitum gymnandrum Maxim
L Chen, M Tian, B Jin, B Yin, T Chen, J Guo… - International Journal of …, 2022 - mdpi.com
Diterpene alkaloids (DAs) are characteristic compounds in Aconitum, which are classified
into four skeletal types: C18, C19, C20, and bisditerpenoid alkaloids. C20-DAs are thought …
into four skeletal types: C18, C19, C20, and bisditerpenoid alkaloids. C20-DAs are thought …
Ribosomal peptides with polycyclic isoprenoid moieties
Isoprenoid modifications of proteins and peptides serve fundamental biological functions
and are of therapeutic interest. While C 15 (farnesyl) and C 20 (geranylgeranyl) moieties are …
and are of therapeutic interest. While C 15 (farnesyl) and C 20 (geranylgeranyl) moieties are …
Alkaloids of Delphinium grandiflorum and their implication to H2O2-induced cardiomyocytes injury
Y Wang, D Sun, Y Chen, J Xu, Y Xu, X Yue, J Jia… - Bioorganic & Medicinal …, 2021 - Elsevier
Abstract Three new diterpenoid alkaloids (1–3), and eight known alkaloids (4–11) were
isolated from the aerial parts of Delphinium grandiflorum. Grandifline A (1) represents an …
isolated from the aerial parts of Delphinium grandiflorum. Grandifline A (1) represents an …
Plant terpenoid permeability through biological membranes explored via molecular simulations
S Raza, M Miller, B Hamberger… - The Journal of Physical …, 2023 - ACS Publications
Plants synthesize small molecule diterpenes composed of 20 carbons from precursor
isopentenyl diphosphate and dimethylallyl disphosphate, manufacturing diverse compounds …
isopentenyl diphosphate and dimethylallyl disphosphate, manufacturing diverse compounds …
Anticancer Diterpenes of African Natural Products: Mechanistic Pathways and Preclinical Developments
G Bangay, FZ Brauning, A Rosatella, AM Díaz-Lanza… - Phytomedicine, 2024 - Elsevier
ABSTRACT Background The African continent is home to five biodiversity hotspots, boasting
an immense wealth of medicinal flora, fungi and marine life. Diterpenes extracted from such …
an immense wealth of medicinal flora, fungi and marine life. Diterpenes extracted from such …