Pituitary adenomas are common tumors of the adenohypophysis which can cause
considerable morbidity, due to excessive hormonal secretion or compression and local …

Prolactinomas constitute the largest group of pituitary adenomas in autopsy series.
However, their relative incidence in recent surgical series is much less impressive since …

Vascular supply is essential for tumor proliferation and metastasis formation. Correlation
was noted between vascular density and tumor size as well as metastases in several tumor …

Human clinically non-functioning pituitary adenomas (NFAs) account for approximately 40%
of diagnosed pituitary tumors. Epigenetic mutations in tumor suppressive genes play an …

Pituitary adenomas (PAs) are common monoclonal tumors arising from adenohypophysis
cells. 1 PAs account for 15% of all intracranial tumors, being the third most common type of …

FROM ANCIENT history throughout the modern age, individuals of extraordinary physical
proportions have figured prominently in myths and tales of magic. The concept of …

We have shown that basic fibroblast growth factor (FGF) is heterogeneously expressed by
human pituitary adenomas and may be implicated as a growth stimulus for these tumors …

The molecular mechanisms leading to increased cellular proliferation rates and, thus, tumor
formation in the anterior pituitary gland are poorly understood. The cyclin-dependent kinase …

Context: The tumorigenic role of genetic abnormalities in sporadic pituitary nonfunctioning
adenomas (NFAs), which usually originate from gonadotroph cells, is unknown. Objective …

The molecular pathogenesis of prolactinomas has resisted elucidation; with the exception of
a RAS mutation in a single aggressive prolactinoma, no mutational changes have been …