Patients with disseminated colorectal cancer have a dismal prognosis with a 5-year survival
rate of only 13%. In order to identify new treatment modalities and new targets, we searched …

Acute myeloid leukemia (AML) is a genetically extremely heterogeneous disease. Drug
resistance after induction therapy is a very frequent event resulting in poor medium survival …

DNA damage in astronauts induced by cosmic radiation poses a major barrier to human
space exploration. Cellular responses and repair of the most lethal DNA double-strand …

Cordyceps sinensis (CS) has been widely used as a dietary supplement or traditional
medicine for the prevention, treatment, and prognostication of various diseases, because of …

Targeted elimination of damaged or overexpressed proteins within the tumor serves a
pivotal role in regulating cellular function and restraining tumor cell growth. Researchers …

Background Lung cancer is a malignant tumor with the highest mortality worldwide.
Abnormalities in the ubiquitin proteasome system are considered to be contributed to lung …

Non-small cell lung cancer (NSCLC) and colorectal cancer (CRC) are associated with a
high mortality rate. Mutations in the V-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog …

The epidermal growth factor receptor (EGFR) tertiary C797S mutation is an important cause
of resistance to Osimertinib, which seriously hinders the clinical application of Osimertinib …

Targeted protein degradation (TPD) is a rapidly growing field in modern drug discovery that
aims to regulate the intracellular levels of proteins by harnessing the cell's innate …

Targeting the programmed cell death protein-1 (PD-1)/programmed cell death-ligand 1 (PD-
L1) pathway has evolved into one of the most promising strategies for tumor immunotherapy …